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<p>This study systematically maps murine in vivo research on small-molecule radiation medical countermeasures (RMCs) published between 2014 and 2024, with quantitative survival analysis focused on whole or total-body irradiation (WBI/TBI) models relevant to hematopoietic acute radiation syndrome (H-ARS). Murine models are central to radiation biology because they provide controlled, reproducible systems for studying radiation injury, testing candidate therapeutics, and generating preclinical evidence relevant to clinical translation. A structured PubMed search identified 5,558 records, of which 258 studies met inclusion criteria. Study characteristics and outcomes were extracted, and survival studies were filtered for (WBI/TBI), appropriate dose range, Kaplan-Meier reporting, and data integrity. To reduce heterogeneity, meta-analysis was restricted to C57BL/6 mice exposed to 7.5–9.5&#xa0;Gy WBI. Of 118 survival studies, 48 cohorts were eligible, but only the 8.0–8.5&#xa0;Gy and 8.5–9.0&#xa0;Gy dose ranges supported quantitative synthesis. Using restricted mean survival time (RMST; τ = 30 days), pooled analysis showed survival gains of 12 and 13 days, respectively, in treated versus control cohorts. Multiple chemically distinct RMCs improved survival, with the largest effects observed for delta-tocotrienol derivatives. These findings highlight both the translational value of murine models and the need for greater standardization in experimental design and reporting.</p>

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Mouse model of radiation mortality: scoping review and meta-analysis of survival outcomes of radiation medical countermeasures

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月2日

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  • Natalie Zivna,
  • Vojtech Chmil,
  • Jan Marek,
  • Ales Tichy,
  • Martina Rezacova,
  • Alena Mrkvicova

摘要

This study systematically maps murine in vivo research on small-molecule radiation medical countermeasures (RMCs) published between 2014 and 2024, with quantitative survival analysis focused on whole or total-body irradiation (WBI/TBI) models relevant to hematopoietic acute radiation syndrome (H-ARS). Murine models are central to radiation biology because they provide controlled, reproducible systems for studying radiation injury, testing candidate therapeutics, and generating preclinical evidence relevant to clinical translation. A structured PubMed search identified 5,558 records, of which 258 studies met inclusion criteria. Study characteristics and outcomes were extracted, and survival studies were filtered for (WBI/TBI), appropriate dose range, Kaplan-Meier reporting, and data integrity. To reduce heterogeneity, meta-analysis was restricted to C57BL/6 mice exposed to 7.5–9.5 Gy WBI. Of 118 survival studies, 48 cohorts were eligible, but only the 8.0–8.5 Gy and 8.5–9.0 Gy dose ranges supported quantitative synthesis. Using restricted mean survival time (RMST; τ = 30 days), pooled analysis showed survival gains of 12 and 13 days, respectively, in treated versus control cohorts. Multiple chemically distinct RMCs improved survival, with the largest effects observed for delta-tocotrienol derivatives. These findings highlight both the translational value of murine models and the need for greater standardization in experimental design and reporting.