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<p>Skin modeling is a crucial tool in dermatology, cosmetics, and pharmaceutical research. However, replicating the skin barrier function in these models remains challenging. Recent advances in lipidomics have highlighted significant differences between skin models and native human skin. Notably, self-assembled tissues exhibit an accumulation of 2-linoleoylglycerol, a monoacylglycerol containing a linoleic acid moiety. This study investigated the impact of 2-linoleoylglycerol on the skin lipidome and testosterone permeability in skin substitutes produced via the self-assembly method. The treatment of skin substitutes with 2-linoleoylglycerol resulted in higher levels of linoleic acid in epidermal phospholipids. Testosterone permeability remained largely unaffected by 2-linoleoylglycerol supplementation, and there was a modest impact on the expression of tight junction proteins. Although monoacylglycerol degradation by monoacylglycerol lipase was unchanged, its synthesis by diacylglycerol lipase β appeared to be influenced by exogenous 2-linoleoylglycerol, since the level of RNA gene transcription was decreased. In conclusion, these results show that the accumulation of 2-linoleoylglycerol in the epidermis of skin substitutes could be one of the factors that affect the lipid metabolism of the skin model.</p>

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Alteration of epidermal lipid metabolism by 2-linoleoylglycerol in a 3D skin model

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月10日

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  • Andréa Tremblay,
  • Mélissa Simard,
  • Angélina Larouche,
  • Élizabeth Dumais,
  • Pierre Julien,
  • Nicolas Flamand,
  • Roxane Pouliot

摘要

Skin modeling is a crucial tool in dermatology, cosmetics, and pharmaceutical research. However, replicating the skin barrier function in these models remains challenging. Recent advances in lipidomics have highlighted significant differences between skin models and native human skin. Notably, self-assembled tissues exhibit an accumulation of 2-linoleoylglycerol, a monoacylglycerol containing a linoleic acid moiety. This study investigated the impact of 2-linoleoylglycerol on the skin lipidome and testosterone permeability in skin substitutes produced via the self-assembly method. The treatment of skin substitutes with 2-linoleoylglycerol resulted in higher levels of linoleic acid in epidermal phospholipids. Testosterone permeability remained largely unaffected by 2-linoleoylglycerol supplementation, and there was a modest impact on the expression of tight junction proteins. Although monoacylglycerol degradation by monoacylglycerol lipase was unchanged, its synthesis by diacylglycerol lipase β appeared to be influenced by exogenous 2-linoleoylglycerol, since the level of RNA gene transcription was decreased. In conclusion, these results show that the accumulation of 2-linoleoylglycerol in the epidermis of skin substitutes could be one of the factors that affect the lipid metabolism of the skin model.