Scholarlink

<p>Cardiometabolic multimorbidity (CMM) and depression are major public health concerns, especially among aging populations. While their bidirectional association is recognized, little is known about how long-term depressive symptom trajectories influence the risk of incident CMM. This 10-year longitudinal study used data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2020). Depressive symptoms were assessed using the CES-D-10 scale, and group-based trajectory modeling identified distinct symptom trajectories. Cox and logistic regression models examined associations between depressive trajectories and new-onset CMM, adjusting for sociodemographic, behavioral, and clinical covariates. Three depressive trajectories were identified: Low-Stable (27.7%), Moderate-Stable (46.3%), and High-Stable (25.9%). Compared to the Low-Stable group, the Moderate-Stable and High-Stable trajectories were associated with significantly increased risks of CMM (adjusted HR = 1.76 and 4.08, respectively). A dose-response relationship was observed between higher CES-D-10 scores and CMM risk. Results remained consistent across subgroups and in sensitivity analyses. Long-term depressive symptom trajectories are independently associated with incident CMM in Chinese middle-aged and older adults. Monitoring depressive symptom dynamics, rather than single assessments, may improve early identification of high-risk individuals and inform integrated prevention strategies targeting both mental and cardiometabolic health.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Depressive symptom trajectories and the risk of cardiometabolic multimorbidity in Chinese middle-aged older adults

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月3日

查看全文
  • Zhiming Song,
  • Shangjin Cheng,
  • Xi Yang,
  • Yang Luo,
  • Qin Quan,
  • Lihong Wei,
  • Xueyin Li,
  • Jianying Song,
  • Jing Liu

摘要

Cardiometabolic multimorbidity (CMM) and depression are major public health concerns, especially among aging populations. While their bidirectional association is recognized, little is known about how long-term depressive symptom trajectories influence the risk of incident CMM. This 10-year longitudinal study used data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2020). Depressive symptoms were assessed using the CES-D-10 scale, and group-based trajectory modeling identified distinct symptom trajectories. Cox and logistic regression models examined associations between depressive trajectories and new-onset CMM, adjusting for sociodemographic, behavioral, and clinical covariates. Three depressive trajectories were identified: Low-Stable (27.7%), Moderate-Stable (46.3%), and High-Stable (25.9%). Compared to the Low-Stable group, the Moderate-Stable and High-Stable trajectories were associated with significantly increased risks of CMM (adjusted HR = 1.76 and 4.08, respectively). A dose-response relationship was observed between higher CES-D-10 scores and CMM risk. Results remained consistent across subgroups and in sensitivity analyses. Long-term depressive symptom trajectories are independently associated with incident CMM in Chinese middle-aged and older adults. Monitoring depressive symptom dynamics, rather than single assessments, may improve early identification of high-risk individuals and inform integrated prevention strategies targeting both mental and cardiometabolic health.