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<p>The epithelial ovarian cancer (EOC) with normal CA125 level is relatively rare. This study aims to develop a nomogram model for predicting the overall survival (OS) of EOC patients with normal CA125 level. A total of 13,068 patients with epithelial ovarian cancer (EOC) were extracted from the SEER database, and an additional 138 patients were recruited from our hospital as an external validation cohort. We found that the OEC patients with normal CA125 levels tend to have a better prognosis than those with elevated CA125 levels. Multivariate Cox regression analysis showed that age, summary stage, histology, and lymphadenectomy status were important factors affecting the prognosis of EOC patients with normal CA125 level.</p>

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Prognostic analysis of epithelial ovarian cancer patients with normal CA125 level: a population-based comparative study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Chuanzhong Liu,
  • Liying Zhang,
  • Yibao Huang,
  • Haijuan Shi,
  • Zhijun Yang

摘要

The epithelial ovarian cancer (EOC) with normal CA125 level is relatively rare. This study aims to develop a nomogram model for predicting the overall survival (OS) of EOC patients with normal CA125 level. A total of 13,068 patients with epithelial ovarian cancer (EOC) were extracted from the SEER database, and an additional 138 patients were recruited from our hospital as an external validation cohort. We found that the OEC patients with normal CA125 levels tend to have a better prognosis than those with elevated CA125 levels. Multivariate Cox regression analysis showed that age, summary stage, histology, and lymphadenectomy status were important factors affecting the prognosis of EOC patients with normal CA125 level.