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<p>Familial Mediterranean Fever (FMF) is a prototypical autoinflammatory disease characterized by recurrent inflammatory attacks and persistent subclinical inflammation. Advanced glycation end products (AGEs) accumulate under conditions of chronic inflammation and oxidative stress and are linked to metabolic and cardiovascular complications. The C-reactive protein–albumin–lymphocyte (CALLY) index has been proposed as a composite biomarker reflecting inflammatory and nutritional status. However, the relationship between tissue AGE accumulation and the CALLY index in FMF remains unclear. This study aimed to evaluate tissue AGE accumulation using skin autofluorescence (AGE-SAF) in patients with FMF and to investigate its associations with the CALLY index, inflammatory markers, metabolic parameters, and clinical characteristics. This cross-sectional study included 87 FMF patients and 52 healthy controls. AGE-SAF was measured non-invasively using an AGE Reader™ device. Clinical and laboratory data were collected, and the CALLY index was calculated from C-reactive protein (CRP), albumin, and lymphocyte count. Non-parametric tests and Spearman’s correlation analyses were applied. AGE-SAF levels were significantly higher in FMF patients than controls (2.06 ± 0.44 vs. 1.70 ± 0.20 AU; <i>p</i> &lt; 0.001). AGE-SAF was elevated in FMF and correlated with inflammatory and metabolic markers, while showing an inverse association with the CALLY index.</p>

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Advanced glycation end products and the CALLY index reflect inflammatory burden in familial Mediterranean fever

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月20日

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摘要

Familial Mediterranean Fever (FMF) is a prototypical autoinflammatory disease characterized by recurrent inflammatory attacks and persistent subclinical inflammation. Advanced glycation end products (AGEs) accumulate under conditions of chronic inflammation and oxidative stress and are linked to metabolic and cardiovascular complications. The C-reactive protein–albumin–lymphocyte (CALLY) index has been proposed as a composite biomarker reflecting inflammatory and nutritional status. However, the relationship between tissue AGE accumulation and the CALLY index in FMF remains unclear. This study aimed to evaluate tissue AGE accumulation using skin autofluorescence (AGE-SAF) in patients with FMF and to investigate its associations with the CALLY index, inflammatory markers, metabolic parameters, and clinical characteristics. This cross-sectional study included 87 FMF patients and 52 healthy controls. AGE-SAF was measured non-invasively using an AGE Reader™ device. Clinical and laboratory data were collected, and the CALLY index was calculated from C-reactive protein (CRP), albumin, and lymphocyte count. Non-parametric tests and Spearman’s correlation analyses were applied. AGE-SAF levels were significantly higher in FMF patients than controls (2.06 ± 0.44 vs. 1.70 ± 0.20 AU; p < 0.001). AGE-SAF was elevated in FMF and correlated with inflammatory and metabolic markers, while showing an inverse association with the CALLY index.