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<p>Recent evidence of inequalities in healthcare for sickle cell disease in the UK is lacking. We aimed to describe trends in hospital admissions for sickle cell anaemia (SCA), cystic fibrosis (CF) and haemophilia in England. We conducted a historical cohort study using Hospital Episode Statistics data of individuals with a primary diagnosis of SCA (<i>n</i> = 19,506), CF (<i>n</i> = 9,569) or haemophilia (<i>n</i> = 7,289) between 1st January 2013 and 31st December 2022. We compared the number and proportion of hospital admissions, 30-day emergency readmissions, length of stay (LoS) and costs of hospitalisations over time for the three conditions considered. The proportion of people with SCA who had frequent elective admissions (i.e.&#xa0;≥ 5&#xa0;per year) was higher and increased over time (43.4% to 52.1% compared with 14.3%-22.3% for CF and 10.4%-14.5% for haemophilia). The proportion of 30-day emergency readmissions was higher for SCA (9.0%) and CF (7.5%) compared with haemophilia (3.2%). Overall mean LoS (days) was longer for people with CF admitted for sepsis (24.3 <i>vs</i>. 16.7 in SCA and 20.8 in haemophilia) and acute appendicitis (6.1 <i>vs</i>. 5.9 for SCA and 5.4 for haemophilia). Estimated hospitalisation costs were higher for SCA (£109.9&#xa0;M) compared with CF (£44.2&#xa0;M) and haemophilia (£14.4&#xa0;M) in 2021/22. We found substantial inequalities in all the indicators considered for SCA, CF and haemophilia. Our findings can inform public health policies to reduce preventable emergency readmissions and healthcare costs.</p>

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A comparative analysis of routine hospital admission data for sickle cell anaemia, cystic fibrosis and haemophilia in England

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月7日

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  • Rutendo Muzambi,
  • Alex Bottle,
  • Mark Layton,
  • Daniel Dexter,
  • Siobhán B. Carr,
  • Carl Reynolds,
  • John James,
  • Cherelle Augustine,
  • Ganesh Sathyamoorthy,
  • Frédéric B. Piel

摘要

Recent evidence of inequalities in healthcare for sickle cell disease in the UK is lacking. We aimed to describe trends in hospital admissions for sickle cell anaemia (SCA), cystic fibrosis (CF) and haemophilia in England. We conducted a historical cohort study using Hospital Episode Statistics data of individuals with a primary diagnosis of SCA (n = 19,506), CF (n = 9,569) or haemophilia (n = 7,289) between 1st January 2013 and 31st December 2022. We compared the number and proportion of hospital admissions, 30-day emergency readmissions, length of stay (LoS) and costs of hospitalisations over time for the three conditions considered. The proportion of people with SCA who had frequent elective admissions (i.e. ≥ 5 per year) was higher and increased over time (43.4% to 52.1% compared with 14.3%-22.3% for CF and 10.4%-14.5% for haemophilia). The proportion of 30-day emergency readmissions was higher for SCA (9.0%) and CF (7.5%) compared with haemophilia (3.2%). Overall mean LoS (days) was longer for people with CF admitted for sepsis (24.3 vs. 16.7 in SCA and 20.8 in haemophilia) and acute appendicitis (6.1 vs. 5.9 for SCA and 5.4 for haemophilia). Estimated hospitalisation costs were higher for SCA (£109.9 M) compared with CF (£44.2 M) and haemophilia (£14.4 M) in 2021/22. We found substantial inequalities in all the indicators considered for SCA, CF and haemophilia. Our findings can inform public health policies to reduce preventable emergency readmissions and healthcare costs.