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<p>Transcranial focused ultrasound stimulation (tFUS) is an emerging non-invasive neuromodulation technique with unique advantages in targeting deep brain structures with high precision. In this study, we investigated the effects of central nucleus of amygdala(CMA)-targeted tFUS on behavior and functional magnetic resonance imaging (fMRI) signals during a facial emotion recognition task involving fearful, neutral, and happy expressions in healthy participants. Participants completed two task sessions in which they received either amygdala-targeted tFUS (n = 24) or control white-matter stimulation (n = 28) prior to the second session. Our results revealed that tFUS significantly impaired the accuracy of fearful and emotional (faerful+happy) face recognition, while simultaneously increasing activity in the CMA. tFUS also reduced functional connectivity between the CMA and the right insula, as well as between CMA and left inferior frontal gyrus/left orbitofrontal cortex. Notably, the CMA-insula connectivity reduction correlated with the observed behavioral performance decline. These effects were spatially specific to the CMA region and its connected networks. These findings provide empirical evidence that tFUS can precisely modulate human amygdala and its network during emotional processing, demonstrating its potential for investigating causal relationships between deep brain networks and behavior.</p>

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Focused ultrasound stimulation of the centromedial amygdala disrupts facial emotion recognition via reduced amygdala–insula connectivity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Yuanzhou Wei,
  • Toshiko Tanaka,
  • Kazuki Enomoto,
  • Masahiko Haruno

摘要

Transcranial focused ultrasound stimulation (tFUS) is an emerging non-invasive neuromodulation technique with unique advantages in targeting deep brain structures with high precision. In this study, we investigated the effects of central nucleus of amygdala(CMA)-targeted tFUS on behavior and functional magnetic resonance imaging (fMRI) signals during a facial emotion recognition task involving fearful, neutral, and happy expressions in healthy participants. Participants completed two task sessions in which they received either amygdala-targeted tFUS (n = 24) or control white-matter stimulation (n = 28) prior to the second session. Our results revealed that tFUS significantly impaired the accuracy of fearful and emotional (faerful+happy) face recognition, while simultaneously increasing activity in the CMA. tFUS also reduced functional connectivity between the CMA and the right insula, as well as between CMA and left inferior frontal gyrus/left orbitofrontal cortex. Notably, the CMA-insula connectivity reduction correlated with the observed behavioral performance decline. These effects were spatially specific to the CMA region and its connected networks. These findings provide empirical evidence that tFUS can precisely modulate human amygdala and its network during emotional processing, demonstrating its potential for investigating causal relationships between deep brain networks and behavior.