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<p>We investigated the effect of weight loss on fat accumulation in six different tissues and associated metabolic characteristics in individuals with obesity, non-alcoholic fatty liver disease (NAFLD), and the metabolic syndrome (MetS).&#xa0;Baseline assessments were done for individuals with obesity, NAFLD, and MetS (n=33), individuals with obesity (n=28), and lean individuals (n=27), and at 1 and 5 months for the NAFLD-MetS group during personalized weight loss intervention.&#xa0;All measured fat depots were increased in individuals with obesity compared with lean (p&lt;0.001), whereas pancreas (p=0.024) and visceral fat (p=0.007) were elevated in the NAFLD-MetS group compared with the obesity control group. During weight loss, fat content was reduced in all investigated tissues after 1- and 5-months, except for erector spinae muscle fat that was reduced after 5 months. Finally, reductions in alanine aminotransferase, fasting plasma glucose and insulin, waist circumference, and diastolic blood pressure were key for explaining liver fat content after 5 months.&#xa0;Multiple fat depots were increased simultaneously in individuals with obesity, with personalized weight loss intervention leading to reductions in all investigated tissues, especially after 1 month, in individuals with obesity, NAFLD, and MetS.&#xa0;The trial registry number: NCT05699863</p>

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Dynamic changes in body fat distribution, ectopic fat, and related metabolic improvement in response to weigt loss in obesity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Malwina Ulanowska,
  • Mimoza Gjela,
  • Morten Hjuler Nielsen,
  • Anders Askeland,
  • Peter Vestergaard,
  • Jens Brøndum Frøkjær,
  • Kurt Højlund,
  • Maiken Mellergaard,
  • Aase Handberg

摘要

We investigated the effect of weight loss on fat accumulation in six different tissues and associated metabolic characteristics in individuals with obesity, non-alcoholic fatty liver disease (NAFLD), and the metabolic syndrome (MetS). Baseline assessments were done for individuals with obesity, NAFLD, and MetS (n=33), individuals with obesity (n=28), and lean individuals (n=27), and at 1 and 5 months for the NAFLD-MetS group during personalized weight loss intervention. All measured fat depots were increased in individuals with obesity compared with lean (p<0.001), whereas pancreas (p=0.024) and visceral fat (p=0.007) were elevated in the NAFLD-MetS group compared with the obesity control group. During weight loss, fat content was reduced in all investigated tissues after 1- and 5-months, except for erector spinae muscle fat that was reduced after 5 months. Finally, reductions in alanine aminotransferase, fasting plasma glucose and insulin, waist circumference, and diastolic blood pressure were key for explaining liver fat content after 5 months. Multiple fat depots were increased simultaneously in individuals with obesity, with personalized weight loss intervention leading to reductions in all investigated tissues, especially after 1 month, in individuals with obesity, NAFLD, and MetS. The trial registry number: NCT05699863