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<p>Healthcare workers (HCW) have been at the frontline during the COVID-19 pandemic, with an increased risk of infection, particularly due to the emergence of the omicron variant. This study aims to assess risk factors for omicron acquisition among vaccinated HCW, comparing hybrid immunity (previous infection and vaccination) to vaccine-induced immunity alone. We took advantage of the COVID-HOP prospective cohort, which includes vaccinated HCW followed over several months, collecting detailed data on demographic characteristics, comorbidities, and professional and personal exposures to COVID-19. We analyzed factors associated with omicron acquisition after January 2022, with a focus on immunization scheme (hybrid or vaccine-induced immunity). Out of 698 HCW analyzed, 298 acquired the omicron variant. In the multivariable analysis (taking into account comorbidities, professional/personal exposure and lifestyle), the two independent factors associated with an increased risk of infection were: younger age (P = 0.005) and immunization scheme (OR associated with vaccine-induced immunity alone: 2.43 [95% Confidence Interval: 1.64–3.60]) with hybrid immunity as reference). HCW with hybrid immunity have a reduced risk of acquiring omicron compared to those with vaccine-induced immunity alone. These findings emphasize the importance of a combined vaccination strategy to better protect HCW against emerging variants, and to vaccine HCW who experienced previous COVID-19 episodes.</p>

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Risk factors for acquisition of SARS-CoV-2 Omicron variant among a prospective cohort of French Healthcare Workers: impact of hybrid immunity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • David Lebeaux,
  • Estelle Lu,
  • Béatrice Parfait,
  • Aurélie Vilfaillot,
  • Cléo Bourgeois,
  • Marie Lachatre,
  • Nathalie Demory,
  • Michaela Semeraro,
  • Bénédicte Sawicki,
  • Damien Sene,
  • Martine Louët,
  • Bruno Pinna,
  • Benoit Védié,
  • Daniela Geromin,
  • Marie-Alexandra Alyanakian,
  • Sarah Tubiana,
  • Philippe Manivet,
  • Jean-Marc Lacorte,
  • Gérard Friedlander,
  • Hélène Péré,
  • Xavier Duval,
  • Pauline Jouany,
  • Juliette Djadi-Prat,
  • Solen Kernéis,
  • Marie Courbebaisse,
  • Damien Sene,
  • Karine Champion,
  • Amanda Lopes,
  • Margaux Monnet,
  • Laure Berton,
  • Luong Liem,
  • Belarbi Linda,
  • Pascal Grange,
  • Aurélie Durel Maurisse,
  • Yu Jin Jung,
  • Paule Puymoyen,
  • Mathilde Favreau,
  • Feriel Meziane,
  • Magatte Fall,
  • Valérie Jolaine,
  • Nathalie Demory-Guinet,
  • Laurence Janot,
  • Martine Louet,
  • Jean-Luc Ecobichon,
  • Elisabeth Gabarra,
  • Laurent Abel,
  • Lynda Bensefa-Colas,
  • Vincent Calvez,
  • Najiby Kassis-Chikhani,
  • Solèn Kerneis,
  • David Veyer,
  • Odile Launay,
  • Dominique Prie,
  • Eric Tartour,
  • Clémence Granier,
  • Lluis Quintana-Murcy,
  • Claire Pernin,
  • Beatrice Parfait,
  • Benoit Girard,
  • Assiya Marah,
  • Anaïs Montegnies,
  • Manon Lesein,
  • Benoit Vedie,
  • Jean-Marc Lacorte,
  • Florian Clavier,
  • Thomas Padilla,
  • Ouifiya Kafif,
  • Céline Sakonda,
  • Flore Rozenberg,
  • Jean-François Meritet,
  • Anne-Geneviève Marcelin,
  • Pauline Rollando,
  • Aurélie Villefaillot,
  • Sébastien Gauthier,
  • Souraya Khouider,
  • Antonin Saldmann,
  • Christian Pinset,
  • François Alhenc-Gelas,
  • Corinne Isnard-Bagnis,
  • Pascal Houillier,
  • Pierre Boutouyrie,
  • Luc Darnige,
  • Raphael Cohen,
  • Philippine Davis

摘要

Healthcare workers (HCW) have been at the frontline during the COVID-19 pandemic, with an increased risk of infection, particularly due to the emergence of the omicron variant. This study aims to assess risk factors for omicron acquisition among vaccinated HCW, comparing hybrid immunity (previous infection and vaccination) to vaccine-induced immunity alone. We took advantage of the COVID-HOP prospective cohort, which includes vaccinated HCW followed over several months, collecting detailed data on demographic characteristics, comorbidities, and professional and personal exposures to COVID-19. We analyzed factors associated with omicron acquisition after January 2022, with a focus on immunization scheme (hybrid or vaccine-induced immunity). Out of 698 HCW analyzed, 298 acquired the omicron variant. In the multivariable analysis (taking into account comorbidities, professional/personal exposure and lifestyle), the two independent factors associated with an increased risk of infection were: younger age (P = 0.005) and immunization scheme (OR associated with vaccine-induced immunity alone: 2.43 [95% Confidence Interval: 1.64–3.60]) with hybrid immunity as reference). HCW with hybrid immunity have a reduced risk of acquiring omicron compared to those with vaccine-induced immunity alone. These findings emphasize the importance of a combined vaccination strategy to better protect HCW against emerging variants, and to vaccine HCW who experienced previous COVID-19 episodes.