Scholarlink

<p>Nanoformulations of natural drugs derived from cyanobacteria can be designed using various nanoparticles, thereby acquiring suitable properties for antimicrobial, cytotoxic, and antioxidant activities. In this study, we aimed to use a combination of natural nanoparticles and propolis to produce a wound healing cream and evaluate its antifungal, cytotoxic, and antioxidant activities through various tests. Four types of creams were prepared: a base cream, a cream containing nanoparticles, a cream containing propolis, and a cream containing both propolis and nanoparticles. The nanoparticles were polyvinyl alcohol/titanium dioxide nanoparticles (PVA/ TiO<sub>2</sub> NCs) extracted from the cyanobacterium <i>Neowestiellopsis persica</i>. The results of measuring the diameter of inhibition zones, minimum inhibitory concentration (MIC), and minimum fungicidal concentration (MFC) of the prepared creams showed that <i>Candida albicans</i> is much more resistant than <i>Trichophyton rubrum.</i> Histological examination of wound samples on day 14 revealed the highest epithelialization and the lowest levels of neutrophils and macrophages in mice treated with the cream containing both propolis and nanoparticles (group 4). Overall, the cream prepared with nanoparticles and propolis demonstrated significant improvement in wound healing compared to the control group. This study is the first to show the effectiveness of a therapeutic cream based on natural ingredients in promoting wound healing in animals.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A cyanobacteria-mediated TiO₂ nanoparticle and propolis cream enhances antifungal activity and wound healing against Candida albicans in mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月14日

查看全文
  • Fateme Ebrahimi Far,
  • Fatemeh Bagheri,
  • Bahareh Nowruzi

摘要

Nanoformulations of natural drugs derived from cyanobacteria can be designed using various nanoparticles, thereby acquiring suitable properties for antimicrobial, cytotoxic, and antioxidant activities. In this study, we aimed to use a combination of natural nanoparticles and propolis to produce a wound healing cream and evaluate its antifungal, cytotoxic, and antioxidant activities through various tests. Four types of creams were prepared: a base cream, a cream containing nanoparticles, a cream containing propolis, and a cream containing both propolis and nanoparticles. The nanoparticles were polyvinyl alcohol/titanium dioxide nanoparticles (PVA/ TiO2 NCs) extracted from the cyanobacterium Neowestiellopsis persica. The results of measuring the diameter of inhibition zones, minimum inhibitory concentration (MIC), and minimum fungicidal concentration (MFC) of the prepared creams showed that Candida albicans is much more resistant than Trichophyton rubrum. Histological examination of wound samples on day 14 revealed the highest epithelialization and the lowest levels of neutrophils and macrophages in mice treated with the cream containing both propolis and nanoparticles (group 4). Overall, the cream prepared with nanoparticles and propolis demonstrated significant improvement in wound healing compared to the control group. This study is the first to show the effectiveness of a therapeutic cream based on natural ingredients in promoting wound healing in animals.