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<p>Diet impacts cardiovascular disease risk, but the association across diabetes subtypes is unclear. We thus aimed to assess the association between dietary factors and estimated 10-year cardiovascular disease risk across diabetes subtypes in the German Diabetes Study (GDS). Participants with recent-onset diabetes and from the 5-year follow-up examination were combined (n=635, mean age 47.5±12.9 years, 60% male) and classified into diabetes subtypes. Subtypes with prevalence &gt;10% were included in cross-sectional analyses: severe autoimmune diabetes (39%), mild obesity-related diabetes (31%), and mild age-related diabetes (30%). Carbohydrate quality parameters and adherence to dietary patterns were assessed from food frequency questionnaires. Differences in associations between these dietary factors and 10-year cardiovascular risk estimated by SCORE2-Diabetes across subtypes were examined using multivariable-adjusted linear regression models including an interaction term. In people with severe autoimmune diabetes, the overall and the healthful plant-based diet index were associated with lower estimated 10-year cardiovascular risk (ß [95% CI] -6.8 [-12.1; -1.2] and -8.8% [-14.0; -3.2] per 1-standard deviation increases, respectively), while these associations were not evident among the remaining two subtypes (p-value for interaction between subtypes &lt;0.05). Our findings suggest subtype-specific associations of plant-based dietary patterns with estimated cardiovascular risk, warranting further research from longitudinal and intervention studies. <b>Trial registration:</b> Clinicaltrials.gov: NCT01055093</p>

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Differential associations of dietary patterns with estimated 10-year cardiovascular risk in diabetes subtypes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Katharina S. Weber,
  • Sabrina Schlesinger,
  • Alexander Lang,
  • Janina Goletzke,
  • Cara Övermöhle,
  • Eike A. Strathmann,
  • Klaus Straßburger,
  • Nitika Singh,
  • Oana-Patricia Zaharia,
  • Sandra Trenkamp,
  • Robert Wagner,
  • Wolfgang Lieb,
  • Anette E. Buyken,
  • Michael Roden,
  • Christian Herder,
  • H. Al-Hasani,
  • B. Belgardt,
  • G.J. Bönhof,
  • G. Geerling,
  • A. Icks,
  • K. Jandeleit-Dahm,
  • O. Kuß,
  • E. Lammert,
  • S. Schlesinger,
  • V. Schrauwen-Hinderling,
  • J. Szendroedi,
  • Sandra Trenkamp

摘要

Diet impacts cardiovascular disease risk, but the association across diabetes subtypes is unclear. We thus aimed to assess the association between dietary factors and estimated 10-year cardiovascular disease risk across diabetes subtypes in the German Diabetes Study (GDS). Participants with recent-onset diabetes and from the 5-year follow-up examination were combined (n=635, mean age 47.5±12.9 years, 60% male) and classified into diabetes subtypes. Subtypes with prevalence >10% were included in cross-sectional analyses: severe autoimmune diabetes (39%), mild obesity-related diabetes (31%), and mild age-related diabetes (30%). Carbohydrate quality parameters and adherence to dietary patterns were assessed from food frequency questionnaires. Differences in associations between these dietary factors and 10-year cardiovascular risk estimated by SCORE2-Diabetes across subtypes were examined using multivariable-adjusted linear regression models including an interaction term. In people with severe autoimmune diabetes, the overall and the healthful plant-based diet index were associated with lower estimated 10-year cardiovascular risk (ß [95% CI] -6.8 [-12.1; -1.2] and -8.8% [-14.0; -3.2] per 1-standard deviation increases, respectively), while these associations were not evident among the remaining two subtypes (p-value for interaction between subtypes <0.05). Our findings suggest subtype-specific associations of plant-based dietary patterns with estimated cardiovascular risk, warranting further research from longitudinal and intervention studies. Trial registration: Clinicaltrials.gov: NCT01055093