Scholarlink

<p>A hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) loaded with silver nanoparticles (AgNPs) was prepared by immersion of HAp/Col powder in the AgNPs solution. The adsorption-desorption properties on the preparation process were investigated, followed by the evaluation of antibacterial activities and cytotoxicity. Adsorption of AgNPs on HAp/Col powder was almost finished at 240&#xa0;min after mixing. Adsorption isotherm revealed that maximum adsorption amount was 1621.9&#xa0;mg/g with the best fitted model, Dubinin-Radushkevich adsorption model. The AgNPs-loaded HAp/Col membrane prepared by immersion into 1.6&#xa0;µg/mL and 6.3&#xa0;µg/mL AgNPs colloidal solution demonstrated no survival of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, respectively. Using human osteoblastic cell line, MG-63, no significant cytotoxicity was observed for the AgNPs-loaded HAp/Col membrane prepared with 6.3–12.5&#xa0;µg/mL AgNPs colloidal solution. These results suggested that AgNPs-loaded HAp/Col would be a good candidate for antibacterial bone void fillers and coating materials for orthopedic and dental implants.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preparation and antibacterial activities of silver nanoparticle-loaded hydroxyapatite/collagen bone-like nanocomposite

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月1日

查看全文
  • Masanori Kikuchi,
  • Taku Yoshida,
  • Yasushi Suetsugu,
  • Akiko Yamamoto

摘要

A hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) loaded with silver nanoparticles (AgNPs) was prepared by immersion of HAp/Col powder in the AgNPs solution. The adsorption-desorption properties on the preparation process were investigated, followed by the evaluation of antibacterial activities and cytotoxicity. Adsorption of AgNPs on HAp/Col powder was almost finished at 240 min after mixing. Adsorption isotherm revealed that maximum adsorption amount was 1621.9 mg/g with the best fitted model, Dubinin-Radushkevich adsorption model. The AgNPs-loaded HAp/Col membrane prepared by immersion into 1.6 µg/mL and 6.3 µg/mL AgNPs colloidal solution demonstrated no survival of Escherichia coli and Staphylococcus aureus, respectively. Using human osteoblastic cell line, MG-63, no significant cytotoxicity was observed for the AgNPs-loaded HAp/Col membrane prepared with 6.3–12.5 µg/mL AgNPs colloidal solution. These results suggested that AgNPs-loaded HAp/Col would be a good candidate for antibacterial bone void fillers and coating materials for orthopedic and dental implants.