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<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease. Therefore, the aim of this study was to investigate the effects of 12 weeks of combined training on biomarkers of liver damage in men with MASLD. Twenty men (38.50 ± 5.52 years, 93.70 ± 11.32&#xa0;kg, 30.67 ± 2.15&#xa0;kg/m<sup>2</sup>) with MASLD were randomly divided into an experimental group and a control group. The experimental group included combined resistance training (RT) with an intensity of 60–75% of the 1RM, high-intensity interval training (HIIT) with an intensity of 84% of the maximum heart rate, and the control group did not receive any intervention. The exercise program included 12 weeks, 3 sessions per week (2 sessions of resistance training, 1 session of HIIT training) and 40–60&#xa0;min in each session. Blood biochemical factors, including omentin-1 and fetuin-B, and liver enzymes, including ALT, AST, ALP, lipid profile (triglyceride, cholesterol, LDL, and HDL), maximal oxygen consumption (VO2max), waist‒hip ratio (WHR), and body fat percentage (BFR), were measured before and after the protocol. Multivariate analysis of covariance (MANCOVA) was used, with pretest values used as covariate variables. Serum levels of fetuin (<i>p</i> &lt; 0.001, η = 0.47) and omentin-1 increased significantly (<i>p</i> = 0.04, η = 0.23), and significant increases in liver enzyme levels (ALT: <i>p</i> &lt; 0.001, η = 0.39; and AST &amp; ALP: <i>p</i> = 0.03, η = 0.25), lipid profiles (TG: <i>p</i> = 0.02, η = 0.27; TC: <i>p</i> = 0.05; η = 0.21; LDL: <i>p</i> = 0.05, η = 0.20; HDL: <i>p</i> = 0.01, η = 0.31), WHR (<i>p</i> = 0.05, η = 0.21), and Vo2max (<i>p</i> = 0.02, η = 0.27) were observed. The results of this study showed that 12 weeks of combined training led to improvements in the lipid profile and liver enzyme levels, which can have a positive effect on MASLD.</p>

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Effects of combined resistance and high-intensity interval training on some biomarkers in men with metabolic dysfunction-associated steatotic liver disease

  • 期刊论文

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  • 发表日期：

    2026年7月9日

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  • Pardis Fazli Mali Darreh,
  • Ali Heidarianpour,
  • Hojjatollah Siavoshy

摘要

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease. Therefore, the aim of this study was to investigate the effects of 12 weeks of combined training on biomarkers of liver damage in men with MASLD. Twenty men (38.50 ± 5.52 years, 93.70 ± 11.32 kg, 30.67 ± 2.15 kg/m2) with MASLD were randomly divided into an experimental group and a control group. The experimental group included combined resistance training (RT) with an intensity of 60–75% of the 1RM, high-intensity interval training (HIIT) with an intensity of 84% of the maximum heart rate, and the control group did not receive any intervention. The exercise program included 12 weeks, 3 sessions per week (2 sessions of resistance training, 1 session of HIIT training) and 40–60 min in each session. Blood biochemical factors, including omentin-1 and fetuin-B, and liver enzymes, including ALT, AST, ALP, lipid profile (triglyceride, cholesterol, LDL, and HDL), maximal oxygen consumption (VO2max), waist‒hip ratio (WHR), and body fat percentage (BFR), were measured before and after the protocol. Multivariate analysis of covariance (MANCOVA) was used, with pretest values used as covariate variables. Serum levels of fetuin (p < 0.001, η = 0.47) and omentin-1 increased significantly (p = 0.04, η = 0.23), and significant increases in liver enzyme levels (ALT: p < 0.001, η = 0.39; and AST & ALP: p = 0.03, η = 0.25), lipid profiles (TG: p = 0.02, η = 0.27; TC: p = 0.05; η = 0.21; LDL: p = 0.05, η = 0.20; HDL: p = 0.01, η = 0.31), WHR (p = 0.05, η = 0.21), and Vo2max (p = 0.02, η = 0.27) were observed. The results of this study showed that 12 weeks of combined training led to improvements in the lipid profile and liver enzyme levels, which can have a positive effect on MASLD.