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<p>Bitter taste disorders are common chemotherapy-induced side effects that compromise nutrition and quality of life. Since no treatment exists for conditions such as bitter taste hypersensitivity and phantogeusia, we hypothesized that a homoeriodictyol sodium (Na-HED) mouthwash reduces chemotherapy-induced bitterness sensitivity caused by salivary platinum (Pt) species derived from intravenously administered carboplatin. In a clinical pilot study involving patients with gynecological cancer (<i>n</i> = 8) receiving carboplatin-based chemotherapy, dietary intake, salivary Pt concentrations, and changes in taste perception were investigated. Patients exhibited decreased energy and protein intake, and salivary Pt. Using an in vitro blood-saliva barrier model, the transfer of Pt-based agents, specifically carboplatin and cisplatin, was demonstrated. Standardized sensory testing in patients revealed increased bitter taste sensitivity compared with the chemo-naïve baseline. A rinse-and-spit solution containing Na-HED, an approved flavoring compound and antagonist of bitter taste receptors (TAS2Rs), reduced the perceived bitterness of caffeine in patients receiving carboplatin (<i>n</i> = 15). As various anticancer agents are predicted to bind to TAS2Rs, a prerequisite for bitter taste sensation, this bitter-masking strategy may have broader applicability. Our preliminary findings show that the Na-HED mouthwash reduces bitter taste sensitivity in patients, supporting its potential to alleviate chemotherapy-induced bitter taste hypersensitivity and phantogeusia.</p>

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A homoeriodictyol sodium mouthwash reduces bitterness sensitivity in patients with gynecological cancer receiving carboplatin-based chemotherapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月2日

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  • Sofie Zehentner,
  • Agnes Mistlberger-Reiner,
  • Elisabeth Wachter,
  • Katja Bacovsky,
  • Michelle Friedrich,
  • Philip Pirkwieser,
  • Valerie Boger,
  • Petra Rust,
  • Sophie Pils,
  • Christoph Grimm,
  • Ana Špilak,
  • Winfried Neuhaus,
  • Jakob Peter Ley,
  • Veronika Somoza

摘要

Bitter taste disorders are common chemotherapy-induced side effects that compromise nutrition and quality of life. Since no treatment exists for conditions such as bitter taste hypersensitivity and phantogeusia, we hypothesized that a homoeriodictyol sodium (Na-HED) mouthwash reduces chemotherapy-induced bitterness sensitivity caused by salivary platinum (Pt) species derived from intravenously administered carboplatin. In a clinical pilot study involving patients with gynecological cancer (n = 8) receiving carboplatin-based chemotherapy, dietary intake, salivary Pt concentrations, and changes in taste perception were investigated. Patients exhibited decreased energy and protein intake, and salivary Pt. Using an in vitro blood-saliva barrier model, the transfer of Pt-based agents, specifically carboplatin and cisplatin, was demonstrated. Standardized sensory testing in patients revealed increased bitter taste sensitivity compared with the chemo-naïve baseline. A rinse-and-spit solution containing Na-HED, an approved flavoring compound and antagonist of bitter taste receptors (TAS2Rs), reduced the perceived bitterness of caffeine in patients receiving carboplatin (n = 15). As various anticancer agents are predicted to bind to TAS2Rs, a prerequisite for bitter taste sensation, this bitter-masking strategy may have broader applicability. Our preliminary findings show that the Na-HED mouthwash reduces bitter taste sensitivity in patients, supporting its potential to alleviate chemotherapy-induced bitter taste hypersensitivity and phantogeusia.