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<p>The geometry of the Circle of Willis poses major challenges for mechanical thrombectomy, where device navigability and effective thrombus removal determine treatment success. This study investigated the performance of venturi-inspired aspiration thrombectomy devices in a simplified cerebral artery segment representative of the middle cerebral artery (MCA), a frequent site of occlusion. Five designs (30°, 45°, 60° venturi, 7/11° taper, and cylindrical control) were assessed using a combined computational–experimental framework. On the computational side, unsteady Reynolds-averaged Navier–Stokes (URANS) simulations were performed in ANSYS Fluent 19.2 with k–ε turbulence closure. Blood–clot interactions were modeled using a Volume of Fluid (VOF) multiphase formulation with Carreau–Yasuda non-Newtonian rheology. In vitro, stereolithography-fabricated prototypes were tested with porcine thrombi in silicone arterial phantoms. CFD predicted extraction times of 2.12&#xa0;s for the control and 1.64&#xa0;s for the 45° venturi, with efficiency plateauing beyond 45°. Experimental results confirmed this trend, showing the 45° design as optimal and all venturi devices outperforming the control. Fragmentation analysis revealed a trade-off, with the 60° venturi producing more than twice the fragments of the 30°. These findings demonstrate that venturi taper geometry critically influences aspiration efficiency and fragmentation and establish CFD–experiment integration as a foundation for optimizing next-generation thrombectomy devices.</p>

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CFD-driven optimization and experimental validation of venturi-based thrombectomy devices in a circle of willis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月18日

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  • Iham F. Zidane,
  • Xiaochen Wang,
  • Hainan He,
  • Xianghong Ma

摘要

The geometry of the Circle of Willis poses major challenges for mechanical thrombectomy, where device navigability and effective thrombus removal determine treatment success. This study investigated the performance of venturi-inspired aspiration thrombectomy devices in a simplified cerebral artery segment representative of the middle cerebral artery (MCA), a frequent site of occlusion. Five designs (30°, 45°, 60° venturi, 7/11° taper, and cylindrical control) were assessed using a combined computational–experimental framework. On the computational side, unsteady Reynolds-averaged Navier–Stokes (URANS) simulations were performed in ANSYS Fluent 19.2 with k–ε turbulence closure. Blood–clot interactions were modeled using a Volume of Fluid (VOF) multiphase formulation with Carreau–Yasuda non-Newtonian rheology. In vitro, stereolithography-fabricated prototypes were tested with porcine thrombi in silicone arterial phantoms. CFD predicted extraction times of 2.12 s for the control and 1.64 s for the 45° venturi, with efficiency plateauing beyond 45°. Experimental results confirmed this trend, showing the 45° design as optimal and all venturi devices outperforming the control. Fragmentation analysis revealed a trade-off, with the 60° venturi producing more than twice the fragments of the 30°. These findings demonstrate that venturi taper geometry critically influences aspiration efficiency and fragmentation and establish CFD–experiment integration as a foundation for optimizing next-generation thrombectomy devices.