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<p>The brain-wide burden of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5–28 years of age demonstrated a robust association of age with PVS count and volume, and an anatomical distribution paralleling that of humans. Preliminary ex vivo microscopy confirmed that an MRI-detected tubular structure corresponded to a perivascular space. These findings begin to establish the rhesus macaque as a tractable model for understanding the role of perivascular function in age-related brain vulnerability.</p>

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Aging macaques bridge the translational gap in perivascular space biology

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月15日

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  • William A. Liguore,
  • Daniel L. Schwartz,
  • Juan Piantino,
  • Avanthika Rajendran,
  • Greg Jensen,
  • Joshua A. Karpf,
  • Mykyta M. Chernov,
  • Randall L. Woltjer,
  • Steven G. Kohama,
  • Lisa C. Silbert,
  • Alison R. Weiss

摘要

The brain-wide burden of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5–28 years of age demonstrated a robust association of age with PVS count and volume, and an anatomical distribution paralleling that of humans. Preliminary ex vivo microscopy confirmed that an MRI-detected tubular structure corresponded to a perivascular space. These findings begin to establish the rhesus macaque as a tractable model for understanding the role of perivascular function in age-related brain vulnerability.