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<p>Preclinical studies of cardiac contractility in rodents are constrained by the invasiveness of current measurement techniques. We investigated whether flow-derived variables obtained by thoracocardiography (TCG), a fully non-invasive technique that does not require surgery, can serve as surrogates for <i>dP/dt</i><sub><i>max</i></sub>. Anesthetized rats were instrumented with both a TCG sensor and a left intraventricular pressure probe to provide the invasive reference. A pharmacological hemodynamic challenge was induced, and four TCG-based indices of early-systolic dynamics—peak aortic velocity (<i>V</i><sub><i>p</i></sub>), peak aortic acceleration (<i>A</i><sub><i>p</i></sub>), mean aortic acceleration (<i>A</i><sub><i>m</i></sub>), and the ratio of <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\({V}_{p}^{2}\)</EquationSource> </InlineEquation> to time-to-peak velocity were quantified and compared with <i>dP/dt</i><sub><i>max</i></sub>. All indices increased during dobutamine infusion and decreased after DL-propranolol injection, paralleling changes in the reference measure. <i>A</i><sub><i>p</i></sub> exhibited the strongest correlation with <i>dP/dt</i><sub><i>max</i></sub> (<i>r</i> = 0.83, <i>p</i> &lt; 0.001). This metric reflects the rapid rise in aortic flow at the onset of ejection and captures the inertial force generated by the ventricle to accelerate the proximal blood column; higher values therefore indicate a stronger contractile performance. These findings provide proof-of-concept that TCG can yield robust contractility surrogates without surgical access, enabling prescreening, longitudinal follow-up and potentially fully non-invasive hemodynamic monitoring in freely moving rodents.</p>

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Non-invasive left ventricular contractility indices derived from thoracocardiography in rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月12日

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  • Leandro Fontana-Pires,
  • Stéphane Tanguy,
  • Agathe Cambier,
  • Charles Eynard,
  • Timothé Flenet,
  • Julie Fontecave-Jallon,
  • Pierre-Yves Gumery,
  • François Boucher

摘要

Preclinical studies of cardiac contractility in rodents are constrained by the invasiveness of current measurement techniques. We investigated whether flow-derived variables obtained by thoracocardiography (TCG), a fully non-invasive technique that does not require surgery, can serve as surrogates for dP/dtmax. Anesthetized rats were instrumented with both a TCG sensor and a left intraventricular pressure probe to provide the invasive reference. A pharmacological hemodynamic challenge was induced, and four TCG-based indices of early-systolic dynamics—peak aortic velocity (Vp), peak aortic acceleration (Ap), mean aortic acceleration (Am), and the ratio of \({V}_{p}^{2}\) to time-to-peak velocity were quantified and compared with dP/dtmax. All indices increased during dobutamine infusion and decreased after DL-propranolol injection, paralleling changes in the reference measure. Ap exhibited the strongest correlation with dP/dtmax (r = 0.83, p < 0.001). This metric reflects the rapid rise in aortic flow at the onset of ejection and captures the inertial force generated by the ventricle to accelerate the proximal blood column; higher values therefore indicate a stronger contractile performance. These findings provide proof-of-concept that TCG can yield robust contractility surrogates without surgical access, enabling prescreening, longitudinal follow-up and potentially fully non-invasive hemodynamic monitoring in freely moving rodents.