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<p>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a global public health concern responsible for a wide range of infections. In Ethiopia, patterns and trends of MRSA in various clinical specimens are limited. Therefore, this study aimed to determine the trend and pattern of <i>S. aureus</i> isolated from 16 AMR surveillance sentinel sites. Laboratory-based AMR surveillance data from 2020 to 2024 was collected from various clinical specimens. Culture and antimicrobial susceptibility testing were performed using standard microbiology techniques. The data were analyzed using WHONET 2025 software version 25.15.5 and SPSS version 22. A total of 4,243 <i>S. aureus</i> isolates were analyzed in 16 AMR sentinel sites; most of them were from health facilities in Addis Ababa (46.6%). The trend of penicillin resistance among tested isolates showed persistently high (~ 90%) between 2020 and 2024. The trend of MRSA showed a noticeable slight decline from 37% in 2021 and 2022 to 30% in the 2024 period, and its overall prevalence was 32.2% (95% CI 30.3, 34.2). There has been a slight declining trend of MRSA since 2022 and fluctuating resistance rates in routinely tested antimicrobials. The susceptibility of isolates to last-resort antibiotics remains promising for treatment. The significant presence of MRSA in participating hospitals warrants continuous surveillance and strengthens the implementation of infection prevention and control measures.</p>

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Trends and patterns of antimicrobial resistance among Staphylococcus aureus isolated from various clinical specimens: a national laboratory-based AMR surveillance, 2020–2024

  • 期刊论文

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  • 发表日期：

    2026年5月9日

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  • Zeleke Ayenew,
  • Meseret Aseffa Oda,
  • Semira Ebrahim Geleto,
  • Tewodros Minwuyelet Anteneh,
  • Etsehiwot Adamu Tsegaye,
  • Yonas Mekonnen Gebeyehu,
  • Dejenie Shiferaw Teklu,
  • Degefu Beyene Gobena,
  • Amete Mihret Teshale,
  • Gebrie Alebachew Belete,
  • Surafel Fentaw Dinku,
  • Tesfa Addis Kefale,
  • Elias Seyoum Derebe,
  • Abera Abdeta Kitaba,
  • Dawit Assefa Wendifraw,
  • Ebisa Fekede,
  • Bruke Gezhagene Birhanu,
  • Mheret Tesfaye Gobena,
  • Addis Abebe,
  • Degefe Habte,
  • Senahara Korsa Wake,
  • Dawit Sekata Duressa,
  • Jemal Mohammed Hussien,
  • Gemechis Bulti Tura,
  • Eshetu Gadisa,
  • Dereje Mamuye Gebretsadik,
  • Daniel Dejene Wondimagegnehu,
  • Daniel Demissie Gebremariam,
  • Birhan Moges Ejigu,
  • Bethelhem Getu Bekele,
  • Estifanos Tsigie,
  • Degu Ashagrie Alemu,
  • Mezgebu Nega Bizuneh,
  • Yesewbelay Minale Negesse,
  • Rajiha Abubeker Ibrahim,
  • Abebe Aseffa Negeri,
  • Getachew Tollera Eticha,
  • Gemechu Tadese Leta,
  • Negga Asamene Abera,
  • Eyasu Tigabu Seyoum

摘要

Methicillin-resistant Staphylococcus aureus (MRSA) is a global public health concern responsible for a wide range of infections. In Ethiopia, patterns and trends of MRSA in various clinical specimens are limited. Therefore, this study aimed to determine the trend and pattern of S. aureus isolated from 16 AMR surveillance sentinel sites. Laboratory-based AMR surveillance data from 2020 to 2024 was collected from various clinical specimens. Culture and antimicrobial susceptibility testing were performed using standard microbiology techniques. The data were analyzed using WHONET 2025 software version 25.15.5 and SPSS version 22. A total of 4,243 S. aureus isolates were analyzed in 16 AMR sentinel sites; most of them were from health facilities in Addis Ababa (46.6%). The trend of penicillin resistance among tested isolates showed persistently high (~ 90%) between 2020 and 2024. The trend of MRSA showed a noticeable slight decline from 37% in 2021 and 2022 to 30% in the 2024 period, and its overall prevalence was 32.2% (95% CI 30.3, 34.2). There has been a slight declining trend of MRSA since 2022 and fluctuating resistance rates in routinely tested antimicrobials. The susceptibility of isolates to last-resort antibiotics remains promising for treatment. The significant presence of MRSA in participating hospitals warrants continuous surveillance and strengthens the implementation of infection prevention and control measures.