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<p>Phytochemical investigation of the non-volatile constituents of <i>Lavandula coronopifolia</i> Poir has led to the isolation of seven compounds (<b>1</b>–<b>7</b>). 2α, 3<i>β</i>, 23-Trihydroxyurs-12,18-dien-28-oic acid 28-<i>O-β</i>-<span>d</span>-glucopyranoside (<b>5</b>) exhibited selective cytotoxic activity against A549 lung carcinoma, with EC<sub>50</sub> value of 11.5 µM, and showed no toxicity towards the normal HEK293T cells. The anti-inflammatory potential of <b>1</b>–<b>7</b> was assessed in lipopolysaccharide (LPS)-stimulated J774A.1 cells. Methyl rosmarinate (<b>2</b>), 1<i>β</i>, 2<i>α</i>, 3<i>β</i>, 19<i>α</i>, 23-pentahydroxy-urs-12-en-28-oic acid-28-<i>O</i>-<i>β</i>-<span>d</span>-glucopyranoside (<b>3</b>) and 2<i>α</i>, 3<i>β</i>, 23-trihydroxyurs-12, 19-dien-28-oic acid 28-<i>O</i>-<i>β</i>-<span>d</span>-glucopyranoside (<b>6</b>) effectively reduced cell migration as revealed by the scratch wound assay. They also altered cell morphology in a manner similar to dexamethasone. Furthermore, qPCR revealed that <b>2</b>, <b>3</b> and <b>6</b> significantly downregulated the expression levels of nitric oxide synthase (iNOS) and interleukin-6 (IL-6) as compared to LPS-stimulated J774A.1 cells. The results highlight the potential of <b>2</b>, <b>3</b> and <b>6</b> for anti-inflammatory therapies and <b>5</b> as a candidate for lung cancer.</p>

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Attenuation of LPS-induced inflammatory responses in J774A.1 macrophages by phenylpropanoids and ursane triterpenes from Lavandula coronopifolia Poir.

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  • 发表日期：

    2026年5月24日

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  • Marwa Elsbaey,
  • Eman Elattar,
  • Álvaro Mourenza,
  • Pablo Castañera,
  • Luis M. Mateos,
  • Michal Letek,
  • Mai H. ElNaggar

摘要

Phytochemical investigation of the non-volatile constituents of Lavandula coronopifolia Poir has led to the isolation of seven compounds (1–7). 2α, 3β, 23-Trihydroxyurs-12,18-dien-28-oic acid 28-O-β-d-glucopyranoside (5) exhibited selective cytotoxic activity against A549 lung carcinoma, with EC50 value of 11.5 µM, and showed no toxicity towards the normal HEK293T cells. The anti-inflammatory potential of 1–7 was assessed in lipopolysaccharide (LPS)-stimulated J774A.1 cells. Methyl rosmarinate (2), 1β, 2α, 3β, 19α, 23-pentahydroxy-urs-12-en-28-oic acid-28-O-β-d-glucopyranoside (3) and 2α, 3β, 23-trihydroxyurs-12, 19-dien-28-oic acid 28-O-β-d-glucopyranoside (6) effectively reduced cell migration as revealed by the scratch wound assay. They also altered cell morphology in a manner similar to dexamethasone. Furthermore, qPCR revealed that 2, 3 and 6 significantly downregulated the expression levels of nitric oxide synthase (iNOS) and interleukin-6 (IL-6) as compared to LPS-stimulated J774A.1 cells. The results highlight the potential of 2, 3 and 6 for anti-inflammatory therapies and 5 as a candidate for lung cancer.