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<p>Psychiatric medication utilization studies rarely identify transgender and gender diverse (TGD) people, masking TGD health inequities. This study assessed antidepressant prescription fill patterns and their predictors among a privately insured TGD sample with newly dispensed anti-depressants after a recent depression or anxiety diagnosis from Merative MarketScan commercial insurance claims from 2007 to 2021. We measured trajectories of antidepressants utilization over 6-months using group-based trajectory modeling (GBTM), then identified demographic and clinical predictors of medication utilization group membership. Among 2499 TGD people with depression or anxiety, we found three anti-depressant dispensing trajectory groups (short-term [21.1%], decreasing [32.3%], and long-term [46.6%]). TGD people with previous chronic co-morbidities or emergency department visits had an increased probability of shorter-term antidepressant dispensing compared to long-term dispensing. TGD people under the age of 25 and those with previous psychotherapy treatment were less likely to have shorter-term anti-depressant dispensing than those with older ages (25–64) and those without prior psychotherapy. This study provides real-world evidence of distinct anti-depressant dispensing patterns and predictive factors associated with shorter-term dispensing among TGD people. Policymakers, providers, and advocacy groups can utilize findings to inform tailored strategies to improve sustained antidepressant use among TGD people living with mental health conditions.</p>

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Trajectories of antidepressant dispensing among privately insured transgender people in the United States

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月28日

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  • Theo Gabriel Beltran,
  • Brian W. Pence,
  • Virginia Pate,
  • Jennifer L. Lund,
  • Tonia C. Poteat,
  • Kathleen C. Thomas,
  • Shabbar I. Ranapurwala,
  • Derrick D. Matthews,
  • Juan M. Hincapie-Castillo

摘要

Psychiatric medication utilization studies rarely identify transgender and gender diverse (TGD) people, masking TGD health inequities. This study assessed antidepressant prescription fill patterns and their predictors among a privately insured TGD sample with newly dispensed anti-depressants after a recent depression or anxiety diagnosis from Merative MarketScan commercial insurance claims from 2007 to 2021. We measured trajectories of antidepressants utilization over 6-months using group-based trajectory modeling (GBTM), then identified demographic and clinical predictors of medication utilization group membership. Among 2499 TGD people with depression or anxiety, we found three anti-depressant dispensing trajectory groups (short-term [21.1%], decreasing [32.3%], and long-term [46.6%]). TGD people with previous chronic co-morbidities or emergency department visits had an increased probability of shorter-term antidepressant dispensing compared to long-term dispensing. TGD people under the age of 25 and those with previous psychotherapy treatment were less likely to have shorter-term anti-depressant dispensing than those with older ages (25–64) and those without prior psychotherapy. This study provides real-world evidence of distinct anti-depressant dispensing patterns and predictive factors associated with shorter-term dispensing among TGD people. Policymakers, providers, and advocacy groups can utilize findings to inform tailored strategies to improve sustained antidepressant use among TGD people living with mental health conditions.