Scholarlink

<p>Sleep-disordered breathing (SDB) during pregnancy may compromise fetal development and brain maturation. Ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) are biomarkers of neuronal injury and cellular stress and may provide insight into fetal vulnerability in this context. UCH-L1 and GFAP concentrations were measured in umbilical cord blood from 85 neonates born to women who underwent hospital-based polysomnography during the third trimester. The apnea-hypopnea index (AHI, and rapid eye movement (REM)-AHI)) and mean nocturnal oxygen saturation (mSaO<sub>2</sub>) were assessed. SDB phenotypes (OSA <i>n</i> = 14; REM-OSA <i>n</i> = 25; and mSaO₂ ≤95% <i>n</i> = 31) showed no significant differences in UCH-L1 or GFAP compared with controls. However, UCH-L1 levels were higher in neonates exposed to shorter apnea-hypopnea (AH) events, and both maternal AH length and mSaO<sub>2</sub> were negatively correlated with UCH-L1 concentrations. Overall, maternal SDB was not broadly associated with differences in UCH-L1 and GFAP levels. Nevertheless, elevated neonatal UCH-L1 linked to non-traditional metrics, such as AH length and mSaO₂, suggests fetal cellular stress and highlights its potential as an early biomarker of neurodevelopment risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Umbilical cord blood biomarkers of neuronal injury in sleep-disordered breathing during pregnancy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月20日

查看全文
  • Laura Cànaves-Gómez,
  • Daniel Morell-Garcia,
  • Jose M. Gonzalez-Alaguero,
  • María Paloma Giménez,
  • Mónica De La Peña Bravo,
  • Ainhoa Álvarez Ruiz De Larrinaga,
  • Andrés Sánchez Baron,
  • Mercedes Codina Marcet,
  • José Peña Zarza,
  • Susana García Fernández,
  • Alberto Alonso-Fernández

摘要

Sleep-disordered breathing (SDB) during pregnancy may compromise fetal development and brain maturation. Ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) are biomarkers of neuronal injury and cellular stress and may provide insight into fetal vulnerability in this context. UCH-L1 and GFAP concentrations were measured in umbilical cord blood from 85 neonates born to women who underwent hospital-based polysomnography during the third trimester. The apnea-hypopnea index (AHI, and rapid eye movement (REM)-AHI)) and mean nocturnal oxygen saturation (mSaO2) were assessed. SDB phenotypes (OSA n = 14; REM-OSA n = 25; and mSaO₂ ≤95% n = 31) showed no significant differences in UCH-L1 or GFAP compared with controls. However, UCH-L1 levels were higher in neonates exposed to shorter apnea-hypopnea (AH) events, and both maternal AH length and mSaO2 were negatively correlated with UCH-L1 concentrations. Overall, maternal SDB was not broadly associated with differences in UCH-L1 and GFAP levels. Nevertheless, elevated neonatal UCH-L1 linked to non-traditional metrics, such as AH length and mSaO₂, suggests fetal cellular stress and highlights its potential as an early biomarker of neurodevelopment risk.