Scholarlink

<p>Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf87 as a previously uncharacterized functional subunit of the MIER corepressor complex that mediates HDAC1 and MIER1 protein interactions. Homozygous knockout of C16orf87 alters chromatin accessibility and reduces cell migration in human cells, and impairs embryonic development of zebrafish. Based on these findings, we propose renaming C16orf87 as HDAC Interacting Protein (HDIP) to reflect its newly revealed function.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月30日

查看全文
  • Tanel Punga,
  • Mårten Larsson,
  • Endrina Mujica,
  • Fabio Rabelo Melo,
  • Christoph Metzendorf,
  • Hanqing Zhang,
  • Dandan Wang,
  • Marcel den Hoed,
  • Leif Andersson,
  • Débora Parrine

摘要

Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf87 as a previously uncharacterized functional subunit of the MIER corepressor complex that mediates HDAC1 and MIER1 protein interactions. Homozygous knockout of C16orf87 alters chromatin accessibility and reduces cell migration in human cells, and impairs embryonic development of zebrafish. Based on these findings, we propose renaming C16orf87 as HDAC Interacting Protein (HDIP) to reflect its newly revealed function.