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<p>Nanozymes have significant potential in human health applications. However, their use in tumor therapy has been restricted by limitations in tumor targeting and retention. Here, we report a 5-fluorouracil (5-Fu)-loaded BSA-palladium nanozyme (FBP) for synergistic treatment of colorectal cancer. The FBP nanozyme was fabricated by conjugation of bovine serum albumin (BSA) with the chemotherapy drug 5-fluorouracil, followed by thermal reduction-mediated precipitation of palladium nanozymes. The BSA shell enhanced biocompatibility and promoted tumor-targeted accumulation via the enhanced permeability and retention (EPR) effect. The FBP nanozyme exhibited both oxidase- and peroxidase-like properties, generating abundant reactive oxygen species to induce tumor cell death. Furthermore, FBP achieved efficient photothermal conversion under 808&#xa0;nm laser irradiation, triggering 5-fluorouracil release and suppressing tumor growth by hyperthermia. This FBP-mediated photothermal ability was effective in eliminating tumors with negligible systemic toxicity. The findings demonstrate the efficacy of this novel nanozyme in combined photothermal treatment for colorectal cancer.</p>

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A 5-fluorouracil-loaded BSA-Pd nanozyme inducing ROS burst and mild photothermal therapy for potent eradication of colorectal cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月4日

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  • Tao Li,
  • Xue Lv,
  • Ziliang Zhang,
  • Shuang Cai,
  • Lefan Liu,
  • Lingyu Zhao

摘要

Nanozymes have significant potential in human health applications. However, their use in tumor therapy has been restricted by limitations in tumor targeting and retention. Here, we report a 5-fluorouracil (5-Fu)-loaded BSA-palladium nanozyme (FBP) for synergistic treatment of colorectal cancer. The FBP nanozyme was fabricated by conjugation of bovine serum albumin (BSA) with the chemotherapy drug 5-fluorouracil, followed by thermal reduction-mediated precipitation of palladium nanozymes. The BSA shell enhanced biocompatibility and promoted tumor-targeted accumulation via the enhanced permeability and retention (EPR) effect. The FBP nanozyme exhibited both oxidase- and peroxidase-like properties, generating abundant reactive oxygen species to induce tumor cell death. Furthermore, FBP achieved efficient photothermal conversion under 808 nm laser irradiation, triggering 5-fluorouracil release and suppressing tumor growth by hyperthermia. This FBP-mediated photothermal ability was effective in eliminating tumors with negligible systemic toxicity. The findings demonstrate the efficacy of this novel nanozyme in combined photothermal treatment for colorectal cancer.