Scholarlink

<p>Epicardial radiofrequency ablation can fail when lesions are not sufficiently deep or transmural, yet intraoperative feedback remains largely indirect. This study presents a fiber-based, side-viewing near-infrared spectroscopy (NIRS) probe with multiple source-detector separations (SDS) to enable depth-sensitive mapping of lesions on the porcine left-ventricular epicardium. Monte Carlo simulations predicted progressively deeper sampling with increasing SDS, motivating the use of multi-separation acquisition for depth-resolved contrast. Experiments were performed on 11 porcine hearts with 133 irrigated epicardial lesions spanning a wide depth range, with lesion depth ground truth reconstructed from post-stain gross section measurements. SDS-dependent spectral signatures were observed across lesions with depths greater than 4&#xa0;mm, lesions with depths ≤ 4&#xa0;mm, adipose tissue, and untreated epicardial muscle, and optical indices capturing these patterns were identified for lesion and adipose classification, as well as for lesion-depth sensitivity. Lesion and adipose indices achieved strong receiver operating characteristic (ROC) performance across SDS (lesion AUC 0.87–0.91; adipose AUC 0.94–0.97), and depth-sensitive indices exhibited monotonic trends with lesion depth (R² up to 0.97). Applying a random forest lesion mask enabled depth-sensitive maps that were consistent with variations in the ground truth.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Side-viewing probe for lesion depth mapping on the left ventricle epicardium with near-infrared spectroscopy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月2日

查看全文
  • Danyang Cheng,
  • Jonah A. Majumder,
  • Haiqiu Yang,
  • Deepak Saluja,
  • Kenneth R. Laurita,
  • Andrew M. Rollins,
  • Christine P. Hendon

摘要

Epicardial radiofrequency ablation can fail when lesions are not sufficiently deep or transmural, yet intraoperative feedback remains largely indirect. This study presents a fiber-based, side-viewing near-infrared spectroscopy (NIRS) probe with multiple source-detector separations (SDS) to enable depth-sensitive mapping of lesions on the porcine left-ventricular epicardium. Monte Carlo simulations predicted progressively deeper sampling with increasing SDS, motivating the use of multi-separation acquisition for depth-resolved contrast. Experiments were performed on 11 porcine hearts with 133 irrigated epicardial lesions spanning a wide depth range, with lesion depth ground truth reconstructed from post-stain gross section measurements. SDS-dependent spectral signatures were observed across lesions with depths greater than 4 mm, lesions with depths ≤ 4 mm, adipose tissue, and untreated epicardial muscle, and optical indices capturing these patterns were identified for lesion and adipose classification, as well as for lesion-depth sensitivity. Lesion and adipose indices achieved strong receiver operating characteristic (ROC) performance across SDS (lesion AUC 0.87–0.91; adipose AUC 0.94–0.97), and depth-sensitive indices exhibited monotonic trends with lesion depth (R² up to 0.97). Applying a random forest lesion mask enabled depth-sensitive maps that were consistent with variations in the ground truth.