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<p>Based on the study, extracts from sea lettuce (<i>Ulva rigida</i>) or UR show significant promise as a natural anti-aging ingredient for skincare products. The research, conducted on specimens from Phetchaburi, Thailand, compared three extraction methods: juice squeezing (J), boiling (B), and maceration (M) by using 95% ethanol. The results demonstrated that these extracts contain beneficial compounds like phenolics and flavonoids, including rutin, catechin, and quercetin, which contribute to their biological properties. Furthermore, all extracts (UR-J, UR-B, and UR-M) exhibited powerful anti-aging effects. Specifically, the UR-M extracts effectively inhibited anti-melanogenesis activity (5.88 ± 1.25%) and the tyrosinase activity (IC<sub>50</sub> of 1.38 ± 0.68&#xa0;mg/ml), and also promoted collagen biosynthesis (37.68 ± 2.24%). All UR extract was particularly notable for its ability to stimulate key anti-aging gene, <i>SIRT1</i>, which is superior to resveratrol (87.8 ± 1.8%). Importantly, none of the extracts showed cytotoxicity at a concentration of 1.0&#xa0;mg/mL, confirming their safety for use on human skin. These findings suggest that the sea lettuce (UR) extracts are a strong candidate for future development as an anti-aging agent in the cosmetic industry.</p>

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Investigating the potential of Ulva rigida extracts as a natural anti-aging agent in cosmetics

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月1日

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  • Korawinwich Boonpisuttinant,
  • Thanachai Taka,
  • Jantana Praiboon,
  • Saranrat Phuangborisut,
  • Nipaporn Kangkawisut,
  • Warintorn Ruksiriwanich,
  • Romchat Chutoprapat,
  • Wirinda Chompoo,
  • Kitrawi Samothai,
  • Sarinporn Udompong,
  • Kulwara Poolpol

摘要

Based on the study, extracts from sea lettuce (Ulva rigida) or UR show significant promise as a natural anti-aging ingredient for skincare products. The research, conducted on specimens from Phetchaburi, Thailand, compared three extraction methods: juice squeezing (J), boiling (B), and maceration (M) by using 95% ethanol. The results demonstrated that these extracts contain beneficial compounds like phenolics and flavonoids, including rutin, catechin, and quercetin, which contribute to their biological properties. Furthermore, all extracts (UR-J, UR-B, and UR-M) exhibited powerful anti-aging effects. Specifically, the UR-M extracts effectively inhibited anti-melanogenesis activity (5.88 ± 1.25%) and the tyrosinase activity (IC50 of 1.38 ± 0.68 mg/ml), and also promoted collagen biosynthesis (37.68 ± 2.24%). All UR extract was particularly notable for its ability to stimulate key anti-aging gene, SIRT1, which is superior to resveratrol (87.8 ± 1.8%). Importantly, none of the extracts showed cytotoxicity at a concentration of 1.0 mg/mL, confirming their safety for use on human skin. These findings suggest that the sea lettuce (UR) extracts are a strong candidate for future development as an anti-aging agent in the cosmetic industry.