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<p>Social isolation is associated with adverse physical and mental health outcomes. However, its relationship with arterial stiffness, a marker of vascular aging and cardiovascular risk, remains unclear. This study aimed to determine the association between social isolation and arterial stiffness in patients aged 55 years or older attending a cardiovascular outpatient clinic. This cross-sectional study included 357 patients (mean age: 72.0 ± 7.6 years; 204 men). Social isolation was assessed using the Lubben Social Network Scale-6 (LSNS-6), and arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV). The LSNS-6 total score was significantly and negatively correlated with baPWV (<i>r</i> = -0.19, <i>p</i> &lt; 0.001). This association remained significant after adjustment for potential confounders (β = -0.146, <i>p</i> = 0.002). Patients with an LSNS-6 total score &lt; 12 had a significantly higher prevalence of arterial stiffening (baPWV ≥ 1800&#xa0;cm/s) than did those with an LSNS-6 total score ≥ 12 (46.7% vs. 34.5%; <i>p</i> = 0.04). Logistic regression analysis revealed that an LSNS-6 total score &lt; 12 was significantly associated with increased risk of arterial stiffening (OR, 2.29; 95% CI, 1.21–4.33; <i>p</i> = 0.01). Although no significant sex interaction was observed, the association appeared stronger in men. These findings suggest that addressing social isolation may serve as a potential strategy to reduce cardiovascular risk.</p>

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Association between social isolation and increased arterial stiffness in older adults: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月24日

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  • Tatsuya Maruhashi,
  • Masato Kajikawa,
  • Shinji Kishimoto,
  • Takayuki Yamaji,
  • Takahiro Harada,
  • Aya Mizobuchi,
  • Shunsuke Tanigawa,
  • Farina Mohamad Yusoff,
  • Yukiko Nakano,
  • Ayumu Nakashima,
  • Chikara Goto,
  • Yukihito Higashi

摘要

Social isolation is associated with adverse physical and mental health outcomes. However, its relationship with arterial stiffness, a marker of vascular aging and cardiovascular risk, remains unclear. This study aimed to determine the association between social isolation and arterial stiffness in patients aged 55 years or older attending a cardiovascular outpatient clinic. This cross-sectional study included 357 patients (mean age: 72.0 ± 7.6 years; 204 men). Social isolation was assessed using the Lubben Social Network Scale-6 (LSNS-6), and arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV). The LSNS-6 total score was significantly and negatively correlated with baPWV (r = -0.19, p < 0.001). This association remained significant after adjustment for potential confounders (β = -0.146, p = 0.002). Patients with an LSNS-6 total score < 12 had a significantly higher prevalence of arterial stiffening (baPWV ≥ 1800 cm/s) than did those with an LSNS-6 total score ≥ 12 (46.7% vs. 34.5%; p = 0.04). Logistic regression analysis revealed that an LSNS-6 total score < 12 was significantly associated with increased risk of arterial stiffening (OR, 2.29; 95% CI, 1.21–4.33; p = 0.01). Although no significant sex interaction was observed, the association appeared stronger in men. These findings suggest that addressing social isolation may serve as a potential strategy to reduce cardiovascular risk.