<p>CO₂ hydrogenation to methanol is a favorable approach due to the vast potential usage of the produced methanol. Apart from copper-based catalysts, indium oxide-based catalysts have been reported as suitable candidates for CO₂ transformation to a highly interesting product such as methanol. In this study, two different ZrO₂ were used as support for laser-generated indium oxide combined with copper or nickel nanoparticles. The prepared catalysts demonstrated strong dependence in their catalytic activity, especially CO₂ conversion and methanol selectivity, on the start form of ZrO₂ support (monoclinic or mixed-phase), and on the metal promoter (copper or nickel). In particular, catalysts prepared with mixed-phase ZrO₂ support showed up to 210% higher CO₂ conversion compared to the monoclinic ZrO₂-supported variants, which is unambiguously connected with the higher specific surface area of the used ZrO₂ crystal modification. Concerning the influence of the metallic co-catalysts, the copper-based catalysts showed up to two times higher yield and selectivity towards methanol compared to those that used nickel oxides. In summary, this study shows the usability of laser-generated nanoparticles as catalysts for the catalyzed hydrogenation of CO₂ to methanol, with certain advantages in relation to the transformation of the initial phase to the form of the active catalyst for the studied reaction.</p>