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<p>Adults with type 1 diabetes mellitus (T1DM) exhibit premature arterial stiffening, but the relative roles of visceral adiposity and recent glycemic variability (GV) remain unclear. We investigated these associations in a group of 120 non-obese adults with T1DM. Pulse wave velocity (PWV) was measured oscillometrically, and visceral fat rating (VFR) was quantified by multifrequency bioimpedance. Ninety-day continuous glucose monitoring data provided glycemic metrics including mean glucose, time in range, time above range, glycemic risk index, mean amplitude of glycemic excursions, mean of daily differences, and coefficient of variation. Participants (median age 33.8&#xa0;years, mean BMI 24.3&#xa0;kg·m⁻<sup>2</sup>) had a mean PWV of 7.47 ± 1.43&#xa0;m·s⁻<sup>1</sup>. Age was the strongest correlate of PWV (ρ = 0.59, p &lt; 0.001) followed by VFR (ρ = 0.48, p &lt; 0.001). In multivariable models, each standard deviation increase in VFR was associated with a 0.22&#xa0;m·s⁻<sup>1</sup> higher PWV (p = 0.01), comparable to the effects of systolic blood pressure and diabetes complications. Ninety-day GV metrics provided only minimal incremental explanatory value (ΔR<sup>2</sup> ≤ 0.08), and none demonstrated significant univariable associations with PWV. VFR and age are dominant correlates of arterial stiffness in T1DM, while recent glycemic variability plays a minor role.</p>

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Visceral fat rating, but not glycemic variability, is strongly associated with arterial stiffness in non-obese adults with type 1 diabetes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月12日

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  • Michal Kulecki,
  • Dariusz Naskret,
  • Maja Mietkiewska-Dolecka,
  • Bartosz Lasowski,
  • Iwona Anderko,
  • Sandra Moska,
  • Anna Lemanska,
  • Paulina Haras,
  • Agata Grzelka-Woźniak,
  • Aleksandra Uruska,
  • Dorota Zozulinska-Ziolkiewicz

摘要

Adults with type 1 diabetes mellitus (T1DM) exhibit premature arterial stiffening, but the relative roles of visceral adiposity and recent glycemic variability (GV) remain unclear. We investigated these associations in a group of 120 non-obese adults with T1DM. Pulse wave velocity (PWV) was measured oscillometrically, and visceral fat rating (VFR) was quantified by multifrequency bioimpedance. Ninety-day continuous glucose monitoring data provided glycemic metrics including mean glucose, time in range, time above range, glycemic risk index, mean amplitude of glycemic excursions, mean of daily differences, and coefficient of variation. Participants (median age 33.8 years, mean BMI 24.3 kg·m⁻2) had a mean PWV of 7.47 ± 1.43 m·s⁻1. Age was the strongest correlate of PWV (ρ = 0.59, p < 0.001) followed by VFR (ρ = 0.48, p < 0.001). In multivariable models, each standard deviation increase in VFR was associated with a 0.22 m·s⁻1 higher PWV (p = 0.01), comparable to the effects of systolic blood pressure and diabetes complications. Ninety-day GV metrics provided only minimal incremental explanatory value (ΔR2 ≤ 0.08), and none demonstrated significant univariable associations with PWV. VFR and age are dominant correlates of arterial stiffness in T1DM, while recent glycemic variability plays a minor role.