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<p>To assess the clinical outcomes of Corneal Allogenic Intrastromal Ring Segments (CAIRS) as a therapeutic approach for keratoconus (KC), with a focus on visual acuity, refractive status, and corneal topographic parameters. In this retrospective analysis, we evaluated the postoperative results of CAIRS (KeraNatural) implantation with a femtosecond laser device corneal tunnel creation in patients with keratoconus with suboptimal visual acuity with spectacles and intolerant to contact lenses. Outcome measures included uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), refractive error, and tomographic keratometry, evaluated both before and after surgery. Follow-up evaluations were conducted at 1&#xa0;day, 1 week, 1 month, 6 months, and annually thereafter. At total of 24 eyes of 22 patients with keratoconus were included in the study. The mean follow-up duration was 8.9 ± 4.9 months. Statistically significant improvements were observed in UCVA, BSCVA, and refractive parameters. Mean UCVA improved from 1.1 ± 0.47 to 0.49 ± 0.30 logMAR (<i>P</i> &lt; 0.001), and BSCVA from 0.35 ± 0.15 to 0.25 ± 0.22 logMAR (<i>P</i> = 0.001). A total of 92% of eyes gained ≥ 3 lines of UCVA, and 46% gained ≥ 6 lines. Manifest astigmatism decreased from − 9.97 ± 4.21 D to − 3.70 ± 1.69 D (<i>P</i> &lt; 0.001). A consistent reduction in Kmax, K1, and K2 values indicated corneal flattening in all eyes. Two eyes (8%) required segment adjustments due to excessive flattening, and two eyes (8%) developed localized inferior pannus. CAIRS implantation demonstrates efficacy in improving visual acuity and corneal tomographic parameters in keratoconus patients. Further research with extended follow-up is warranted to establish the long-term safety and durability of this technique.</p>

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Corneal allogenic intrastromal ring segments for the treatment of keratoconus

  • 期刊论文

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  • 发表日期：

    2026年7月30日

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  • Ramez Barbara,
  • Gabriella De Salvo,
  • Rana Hanna,
  • Anastasios Sepetis,
  • Norma Lucia Espinoza,
  • Joseph Pickel,
  • Beatrice Tiosano,
  • Adel Barbara

摘要

To assess the clinical outcomes of Corneal Allogenic Intrastromal Ring Segments (CAIRS) as a therapeutic approach for keratoconus (KC), with a focus on visual acuity, refractive status, and corneal topographic parameters. In this retrospective analysis, we evaluated the postoperative results of CAIRS (KeraNatural) implantation with a femtosecond laser device corneal tunnel creation in patients with keratoconus with suboptimal visual acuity with spectacles and intolerant to contact lenses. Outcome measures included uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), refractive error, and tomographic keratometry, evaluated both before and after surgery. Follow-up evaluations were conducted at 1 day, 1 week, 1 month, 6 months, and annually thereafter. At total of 24 eyes of 22 patients with keratoconus were included in the study. The mean follow-up duration was 8.9 ± 4.9 months. Statistically significant improvements were observed in UCVA, BSCVA, and refractive parameters. Mean UCVA improved from 1.1 ± 0.47 to 0.49 ± 0.30 logMAR (P < 0.001), and BSCVA from 0.35 ± 0.15 to 0.25 ± 0.22 logMAR (P = 0.001). A total of 92% of eyes gained ≥ 3 lines of UCVA, and 46% gained ≥ 6 lines. Manifest astigmatism decreased from − 9.97 ± 4.21 D to − 3.70 ± 1.69 D (P < 0.001). A consistent reduction in Kmax, K1, and K2 values indicated corneal flattening in all eyes. Two eyes (8%) required segment adjustments due to excessive flattening, and two eyes (8%) developed localized inferior pannus. CAIRS implantation demonstrates efficacy in improving visual acuity and corneal tomographic parameters in keratoconus patients. Further research with extended follow-up is warranted to establish the long-term safety and durability of this technique.