Scholarlink

<p>This study aimed to compare exercise capacity (EC) and comorbidity profiles across left ventricular ejection fraction (LVEF) defined heart failure (HF) categories. From a retrospective, single-centre registry, we analysed 196 individuals with established HF who underwent cardiopulmonary exercise testing and a 6&#xa0;min walk test (6MWT). EC differed significantly across LVEF categories but not in a linear fashion. The percent of predicted peak oxygen uptake (VO₂) was significantly lower in HF with reduced LVEF (HFrEF, <i>n</i> = 89) than in HF with preserved LVEF (HFpEF, <i>n</i> = 36) and HF with mildly reduced LVEF (HFmrEF, <i>n</i> = 71) (65.9% vs. 76.6% and 76.8%, <i>p</i> &lt; 0.001). Ventilatory inefficiency (VE/VCO₂ slope) was more pronounced in HFrEF than in HFpEF (35.3 vs. 31.7; <i>p</i> = 0.002), while the proportion with VE/VCO₂ slope &gt; 36 did not differ across groups. The achieved workload and 6MWT distance were comparable across groups. Comorbidity profiles diverged meaningfully: HFmrEF had the lowest prevalence of chronic kidney disease (<i>p</i> = 0.009) and type 2 diabetes (<i>p</i> = 0.025). Notably, HFpEF exhibited the highest prevalence of anaemia (<i>p</i> = 0.0013). HFmrEF displays an EC profile closer to HFpEF than to HFrEF, while anaemia emerges as a particularly important comorbidity in HFpEF.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A non-linear pattern of exercise capacity in heart failure across ejection fraction categories

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月2日

查看全文
  • Małgorzata Kurpaska,
  • Paweł Krzesiński,
  • Martyna Świerkowska,
  • Katarzyna Piotrowicz

摘要

This study aimed to compare exercise capacity (EC) and comorbidity profiles across left ventricular ejection fraction (LVEF) defined heart failure (HF) categories. From a retrospective, single-centre registry, we analysed 196 individuals with established HF who underwent cardiopulmonary exercise testing and a 6 min walk test (6MWT). EC differed significantly across LVEF categories but not in a linear fashion. The percent of predicted peak oxygen uptake (VO₂) was significantly lower in HF with reduced LVEF (HFrEF, n = 89) than in HF with preserved LVEF (HFpEF, n = 36) and HF with mildly reduced LVEF (HFmrEF, n = 71) (65.9% vs. 76.6% and 76.8%, p < 0.001). Ventilatory inefficiency (VE/VCO₂ slope) was more pronounced in HFrEF than in HFpEF (35.3 vs. 31.7; p = 0.002), while the proportion with VE/VCO₂ slope > 36 did not differ across groups. The achieved workload and 6MWT distance were comparable across groups. Comorbidity profiles diverged meaningfully: HFmrEF had the lowest prevalence of chronic kidney disease (p = 0.009) and type 2 diabetes (p = 0.025). Notably, HFpEF exhibited the highest prevalence of anaemia (p = 0.0013). HFmrEF displays an EC profile closer to HFpEF than to HFrEF, while anaemia emerges as a particularly important comorbidity in HFpEF.