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<p>Neovascular glaucoma (NVG) is a severe, vision-threatening secondary glaucoma associated with ocular ischemia and systemic vascular disease. Whether NVG also serves as a marker of systemic vascular risk remains unclear. In this retrospective, multicenter cohort study, adults with NVG were identified from a global electronic health record network and 1:1 propensity score matched to controls, accounting for demographics, comorbidities, medications, and healthcare utilization. Follow-up was up to 10&#xa0;years. Primary outcomes were all-cause mortality, myocardial infarction, stroke, cardiac arrest, and three-point major adverse cardiovascular events (3P-MACE). Sensitivity analyses compared NVG with primary open-angle glaucoma (POAG) and examined subgroups with proliferative diabetic retinopathy, retinal vein occlusion, or ocular ischemic syndrome. Among 17,020 matched pairs, NVG was associated with higher risks of all-cause mortality (HR 1.70, 95% CI 1.60–1.81), myocardial infarction (HR 1.53, 95% CI 1.40–1.67), cardiac arrest (HR 1.57, 95% CI 1.36–1.82), stroke (HR 1.62, 95% CI 1.48–1.79), and 3P-MACE (HR 1.59, 95% CI 1.51–1.68). Findings were consistent across sensitivity and ischemic retinal subgroups. NVG is associated with increased long-term mortality and cardiovascular events, suggesting that its occurrence may identify patients with higher systemic vascular risks and supporting the need for proactive cardiovascular assessment.</p>

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Association of neovascular glaucoma with increased mortality and cardiovascular risk: a multicenter propensity-matched study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月5日

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  • Yossi Eshel,
  • Shoham Kubovsky,
  • Natan Lishinsky-Fischer,
  • Tehila Shlomov,
  • Itay Nitzan,
  • Itay Chowers,
  • Jaime Levy

摘要

Neovascular glaucoma (NVG) is a severe, vision-threatening secondary glaucoma associated with ocular ischemia and systemic vascular disease. Whether NVG also serves as a marker of systemic vascular risk remains unclear. In this retrospective, multicenter cohort study, adults with NVG were identified from a global electronic health record network and 1:1 propensity score matched to controls, accounting for demographics, comorbidities, medications, and healthcare utilization. Follow-up was up to 10 years. Primary outcomes were all-cause mortality, myocardial infarction, stroke, cardiac arrest, and three-point major adverse cardiovascular events (3P-MACE). Sensitivity analyses compared NVG with primary open-angle glaucoma (POAG) and examined subgroups with proliferative diabetic retinopathy, retinal vein occlusion, or ocular ischemic syndrome. Among 17,020 matched pairs, NVG was associated with higher risks of all-cause mortality (HR 1.70, 95% CI 1.60–1.81), myocardial infarction (HR 1.53, 95% CI 1.40–1.67), cardiac arrest (HR 1.57, 95% CI 1.36–1.82), stroke (HR 1.62, 95% CI 1.48–1.79), and 3P-MACE (HR 1.59, 95% CI 1.51–1.68). Findings were consistent across sensitivity and ischemic retinal subgroups. NVG is associated with increased long-term mortality and cardiovascular events, suggesting that its occurrence may identify patients with higher systemic vascular risks and supporting the need for proactive cardiovascular assessment.