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<p>Brain modeling has emerged as a fundamental tool for understanding neural mechanisms and information processing across different spatial and temporal scales. However, the simulation and visualization of realistic full-scale neural models remain a challenge. To address this, we developed the Neural Circuit Visualizer (NCV), a web-based platform for the flexible simulation and visualization of full-scale point-neuron circuits. We integrated state-of-the-art scientific advances, such as region-specific connectivity and the anatomical reconstruction of the mouse right hippocampal CA1 region, with resources and services from mature research infrastructures (e.g., Hippocampome.org, ebrains.eu, ebrains-italy.eu) and high-performance computing (HPC) facilities. The resulting online tool provides a public resource for the simulation and visualization of neural dynamics in full-scale point-neuron models and fosters the comprehension of neural mechanisms under physiological and pathological conditions. The tool is released as open source to encourage further collaborative development and integration.</p>

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Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月20日

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  • Maqsood Ali,
  • Roberto Smiriglia,
  • Emiliano Spera,
  • Safeer A. Mirani,
  • Sergio M.G. Solinas,
  • Michele Migliore,
  • Giorgio A. Ascoli,
  • Luca L. Bologna

摘要

Brain modeling has emerged as a fundamental tool for understanding neural mechanisms and information processing across different spatial and temporal scales. However, the simulation and visualization of realistic full-scale neural models remain a challenge. To address this, we developed the Neural Circuit Visualizer (NCV), a web-based platform for the flexible simulation and visualization of full-scale point-neuron circuits. We integrated state-of-the-art scientific advances, such as region-specific connectivity and the anatomical reconstruction of the mouse right hippocampal CA1 region, with resources and services from mature research infrastructures (e.g., Hippocampome.org, ebrains.eu, ebrains-italy.eu) and high-performance computing (HPC) facilities. The resulting online tool provides a public resource for the simulation and visualization of neural dynamics in full-scale point-neuron models and fosters the comprehension of neural mechanisms under physiological and pathological conditions. The tool is released as open source to encourage further collaborative development and integration.