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<p>Urinary tract infections (UTIs), particularly catheter-associated UTIs (CAUTIs), pose significant global health challenges. In this study, chitosan-silver nanoparticles loaded with nitrofurantoin (NFT*C@AgNPs) were utilized to combat CAUTIs, highlighting their strong antimicrobial potential. The physicochemical characterization was performed using UV–Vis, FT-IR, XRD, Zeta Potential, FE-SEM, TGA, and ICP-OES. Drug release studies revealed a linear release profile (R<sup>2</sup> = 0.94205) under simulated physiological conditions (pH 7.4), with maximum release achieved within 1&#xa0;h, suggesting controlled release potential. Antimicrobial assays demonstrated significant activity against <i>S. aureus</i> and <i>E. coli</i>, with MIC values of 31.25&#xa0;µg/ml and 15.62&#xa0;µg/ml, respectively. Notably, NFT*C@AgNPs exhibited superior efficacy against <i>E. coli</i> compared to gentamicin. Antibiofilm studies further revealed potent inhibition at 31.25&#xa0;µg/ml against <i>S. aureus</i> and at 15.62&#xa0;µg/ml against <i>E. coli</i>, both of which surpassed gentamicin. Cytotoxicity assessment indicated negligible toxicity towards normal human cells, confirming their biocompatibility for clinical applications. Furthermore, catheter surface coating with NFT*C@AgNPs demonstrated potential for preventing UTIs with enhanced safety. Overall, these findings suggest that NFT*C@AgNPs are an effective antimicrobial nanomaterial for preventing UTIs and catheter-associated infections.</p>

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Fabrication of nitrofurantoin-loaded chitosan-silver nanoparticles for the treatment of urinary tract infections

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月18日

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  • G. N. Ningaraju,
  • S. Nanjundaswamy,
  • Mohammed Ghazwani,
  • Yahya Alhamhoom,
  • Riyaz Ali M. Osmani,
  • Mano Govindharaj,
  • Fawzi Banat,
  • C. S. Karthik

摘要

Urinary tract infections (UTIs), particularly catheter-associated UTIs (CAUTIs), pose significant global health challenges. In this study, chitosan-silver nanoparticles loaded with nitrofurantoin (NFT*C@AgNPs) were utilized to combat CAUTIs, highlighting their strong antimicrobial potential. The physicochemical characterization was performed using UV–Vis, FT-IR, XRD, Zeta Potential, FE-SEM, TGA, and ICP-OES. Drug release studies revealed a linear release profile (R2 = 0.94205) under simulated physiological conditions (pH 7.4), with maximum release achieved within 1 h, suggesting controlled release potential. Antimicrobial assays demonstrated significant activity against S. aureus and E. coli, with MIC values of 31.25 µg/ml and 15.62 µg/ml, respectively. Notably, NFT*C@AgNPs exhibited superior efficacy against E. coli compared to gentamicin. Antibiofilm studies further revealed potent inhibition at 31.25 µg/ml against S. aureus and at 15.62 µg/ml against E. coli, both of which surpassed gentamicin. Cytotoxicity assessment indicated negligible toxicity towards normal human cells, confirming their biocompatibility for clinical applications. Furthermore, catheter surface coating with NFT*C@AgNPs demonstrated potential for preventing UTIs with enhanced safety. Overall, these findings suggest that NFT*C@AgNPs are an effective antimicrobial nanomaterial for preventing UTIs and catheter-associated infections.