Scholarlink

<p>A novel electrochemical sensor based on multi-walled carbon nanotubes doped with vanadium pentoxide/telluride (MWCNTs@V<sub>2</sub>O<sub>5</sub>/Te) was developed for the detection and quantification of morphine sulfate in real biological samples. MWCNTs@V<sub>2</sub>O<sub>5</sub>/Te nanocomposite was functionalized with cysteamine as a linker, to create thiol interaction with the -OH group of the MWCNTs@V<sub>2</sub>O<sub>5</sub>/Te nanocomposite at one end, and free -NH<sub>2</sub> group interaction with the -OH group on morphine sulfate, on the other end. This modification enhances the conjugation capability of morphine sulfate with the fabricated biosensor.&#xa0;(MWCNTs@V<sub>2</sub>O<sub>5</sub>/Te-Cys/GCE). MWCNTs@V<sub>2</sub>O<sub>5</sub>/Te nanocomposite morphological and structural analysis is carried out by SEM, TEM, EDX, FTIR, and UV-Vis spectroscopy. At varying concentrations and pH levels, the electrochemical sensor response of the modified electrode is investigated using cyclic voltammetry (CV). To validate the findings, differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and chronoamperometry are employed to investigate morphine sulfate detection, yielding excellent results in real biological samples. The fabricated sensor, as indicated by the calibration curve, exhibits a wide linear range of 10–60 µM and a limit of detection (LOD) of 0.01&#xa0;µM by DPV. These results reveal that this novel sensor is highly stable, sensitive, and reproducible for detecting morphine sulfate. Therefore, this developed sensing platform can be used in clinical diagnostics, narcotics detection, and forensic analysis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Highly sensitive electrochemical detection and quantification of opium derived morphine sulfate using cysteamine loaded MWCNTs@V2O5 telluride composite

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月15日

查看全文
  • Sana Shaheen,
  • Batool Fatima,
  • Dilshad Hussain,
  • Ayub Alam,
  • Muhammad Ayub,
  • Muhammad Najam-ul-Haq

摘要

A novel electrochemical sensor based on multi-walled carbon nanotubes doped with vanadium pentoxide/telluride (MWCNTs@V2O5/Te) was developed for the detection and quantification of morphine sulfate in real biological samples. MWCNTs@V2O5/Te nanocomposite was functionalized with cysteamine as a linker, to create thiol interaction with the -OH group of the MWCNTs@V2O5/Te nanocomposite at one end, and free -NH2 group interaction with the -OH group on morphine sulfate, on the other end. This modification enhances the conjugation capability of morphine sulfate with the fabricated biosensor. (MWCNTs@V2O5/Te-Cys/GCE). MWCNTs@V2O5/Te nanocomposite morphological and structural analysis is carried out by SEM, TEM, EDX, FTIR, and UV-Vis spectroscopy. At varying concentrations and pH levels, the electrochemical sensor response of the modified electrode is investigated using cyclic voltammetry (CV). To validate the findings, differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and chronoamperometry are employed to investigate morphine sulfate detection, yielding excellent results in real biological samples. The fabricated sensor, as indicated by the calibration curve, exhibits a wide linear range of 10–60 µM and a limit of detection (LOD) of 0.01 µM by DPV. These results reveal that this novel sensor is highly stable, sensitive, and reproducible for detecting morphine sulfate. Therefore, this developed sensing platform can be used in clinical diagnostics, narcotics detection, and forensic analysis.