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<p>Osteomyelitis, surgical site infections, implant infections, abscesses, and other localized infections can be difficult to treat due to poor vascularity, biofilm formation, and the presence of antibiotic-resistant bacteria. These infections result in significant morbidity and mortality in human and veterinary patients. Local delivery of high concentrations of antibiotics that are released over a prolonged period of time can overcome these issues, and avoid side effects of systemic antibiotics. In vitro release kinetics of amikacin, clindamycin, and vancomycin from a cross-linked dextran (CLD) gel were investigated. The hypothesis was that CLD gel containing vancomycin, amikacin, clindamycin or a combination of amikacin and clindamycin would elute concentrations above the MIC of common bacterial pathogens for 7 days in vitro. Elution kinetics of CLD gels impregnated with each antibiotic and control gel were tested an <i>in vitro.</i> Each gel was incubated with phosphate-buffered saline at 37&#xa0;°C with agitation in triplicate. The media was changed every 24&#xa0;h. Samples from the experimental and control gels were collected for a period of 16 days and antibiotic concentrations were determined. Mean antibiotic concentrations from CLD gel remained above the MIC for at least 7 days for each of the antibiotics investigated. Peak mean antibiotic concentrations occurred at 24&#xa0;h. In sum, there is reliable elution over 7 days of amikacin, clindamycin and vancomycin from CLD gel at clinically relevant concentrations.</p>

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Sustained elution of amikacin, clindamycin, and vancomycin from a biodegradable cross-linked dextran gel

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月19日

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  • Jennifer G. Barrett,
  • Jennifer A. Raffetto,
  • Mark G. Papich,
  • Kenneth E. Sullins

摘要

Osteomyelitis, surgical site infections, implant infections, abscesses, and other localized infections can be difficult to treat due to poor vascularity, biofilm formation, and the presence of antibiotic-resistant bacteria. These infections result in significant morbidity and mortality in human and veterinary patients. Local delivery of high concentrations of antibiotics that are released over a prolonged period of time can overcome these issues, and avoid side effects of systemic antibiotics. In vitro release kinetics of amikacin, clindamycin, and vancomycin from a cross-linked dextran (CLD) gel were investigated. The hypothesis was that CLD gel containing vancomycin, amikacin, clindamycin or a combination of amikacin and clindamycin would elute concentrations above the MIC of common bacterial pathogens for 7 days in vitro. Elution kinetics of CLD gels impregnated with each antibiotic and control gel were tested an in vitro. Each gel was incubated with phosphate-buffered saline at 37 °C with agitation in triplicate. The media was changed every 24 h. Samples from the experimental and control gels were collected for a period of 16 days and antibiotic concentrations were determined. Mean antibiotic concentrations from CLD gel remained above the MIC for at least 7 days for each of the antibiotics investigated. Peak mean antibiotic concentrations occurred at 24 h. In sum, there is reliable elution over 7 days of amikacin, clindamycin and vancomycin from CLD gel at clinically relevant concentrations.