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<p><i>PRAC1</i>, which is specifically expressed in prostate, rectal, and distal colon tissues, plays a critical role in the maintenance and self-renewal of prostate epithelial stem cells. However, the role of <i>PRAC1</i> in prostate cancer is unclear. In this study, we found that <i>PRAC1</i> expression is upregulated in prostate cancer cells and that <i>PRAC1</i> knockdown represses the proliferation of prostate cancer cells. Moreover, lysine-specific demethylase 1 (LSD1) promoted prostate cancer cell proliferation by upregulating <i>PRAC1</i> expression. TAK-418, an LSD1 inhibitor, suppressed prostate cancer cell proliferation by downregulating <i>PRAC1</i> expression. Our results highlight <i>PRAC1</i> or LSD1 inhibition as promising avenues for prostate cancer treatment.</p>

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LSD1 promotes prostate cancer cell proliferation by upregulating PRAC1 expression

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月10日

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  • Yang Liao,
  • Chuan Liu

摘要

PRAC1, which is specifically expressed in prostate, rectal, and distal colon tissues, plays a critical role in the maintenance and self-renewal of prostate epithelial stem cells. However, the role of PRAC1 in prostate cancer is unclear. In this study, we found that PRAC1 expression is upregulated in prostate cancer cells and that PRAC1 knockdown represses the proliferation of prostate cancer cells. Moreover, lysine-specific demethylase 1 (LSD1) promoted prostate cancer cell proliferation by upregulating PRAC1 expression. TAK-418, an LSD1 inhibitor, suppressed prostate cancer cell proliferation by downregulating PRAC1 expression. Our results highlight PRAC1 or LSD1 inhibition as promising avenues for prostate cancer treatment.