Scholarlink

<p>The increasing demand for sustainable alternatives to in-feed antibiotics in animal production underscores the scarcity of thorough research on natural bioactive carriers that endure gastrointestinal digestion and offer multiple benefits. This study explored the potential of camel milk extracellular vesicles (CM-EVs) as natural alternatives to antibiotics in animal production. The research evaluated the gastrointestinal stability and multifunctional properties of CM-EVs through in vitro analysis. Simulated digestion experiments revealed that CM-EVs maintained their structural integrity throughout the gastrointestinal tract. Furthermore, they exhibited significant dose-dependent antioxidant activity and demonstrated effective antimicrobial properties against <i>Escherichia coli</i> and <i>Staphylococcus epidermidis</i>. In macrophage models, CM-EVs enhanced cell viability and selectively reduced the release of IL-1β and IL-6, without affecting TNF-α levels. These results indicate that CM-EVs are stable during digestion and possess antioxidant, antimicrobial, and immunomodulatory properties, highlighting their potential as a natural supplement to enhance animal health and reduce reliance on conventional antibiotics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Camel milk extracellular vesicles as a promising antibiotic alternative: gastrointestinal stability, antimicrobial, and immunoregulatory activities

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月3日

查看全文
  • Jiaotong Fu,
  • Longxia Fu,
  • Bintao Zhai,
  • Huiyu Shi,
  • Hui Yang

摘要

The increasing demand for sustainable alternatives to in-feed antibiotics in animal production underscores the scarcity of thorough research on natural bioactive carriers that endure gastrointestinal digestion and offer multiple benefits. This study explored the potential of camel milk extracellular vesicles (CM-EVs) as natural alternatives to antibiotics in animal production. The research evaluated the gastrointestinal stability and multifunctional properties of CM-EVs through in vitro analysis. Simulated digestion experiments revealed that CM-EVs maintained their structural integrity throughout the gastrointestinal tract. Furthermore, they exhibited significant dose-dependent antioxidant activity and demonstrated effective antimicrobial properties against Escherichia coli and Staphylococcus epidermidis. In macrophage models, CM-EVs enhanced cell viability and selectively reduced the release of IL-1β and IL-6, without affecting TNF-α levels. These results indicate that CM-EVs are stable during digestion and possess antioxidant, antimicrobial, and immunomodulatory properties, highlighting their potential as a natural supplement to enhance animal health and reduce reliance on conventional antibiotics.