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<p>This study reports the chemical profiling and antimicrobial potential of <i>Opuntia ficus-indica</i> seed oil from Eastern Morocco, with emphasis on pharmacologically relevant constituents and valorization of an underexploited by-product. Seed oil was obtained by cold mechanical pressing and characterized using GC–MS (fatty acids and volatile profile), HPLC–DAD (tocopherols), and UHPLC–MS/MS (phenolic constituents). The oil exhibited a PUFA-rich profile dominated by linoleic acid (73.94%), with palmitic and stearic acids as major saturated components, while oleic acid was not detected under our analytical conditions. Tocopherol analysis revealed a high γ-tocopherol level (657.52&#xa0;mg/kg). UHPLC–MS/MS enabled annotation of multiple phenolic compounds, including arbutin and kaempferol as major constituents. In vitro antibacterial assays showed no inhibition against <i>Staphylococcus aureus</i> and <i>Streptococcus</i> spp. (inhibition zone &lt; 7&#xa0;mm), whereas moderate-to-high activity was observed against <i>Escherichia coli</i> (11.6 ± 0.64&#xa0;mm) and <i>Klebsiella</i> spp. (15.6 ± 0.51&#xa0;mm). In silico POM analysis supported favorable drug-likeness/toxicological profiles for arbutin and kaempferol. Overall, these results support <i>O. ficus-indica</i> seed oil as a chemically rich natural matrix with promising antioxidant and antibacterial potential.</p>

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Applications of Opuntia ficus-indica (L.) mill seed oil from eastern morocco including chemical profiling, antibacterial activity, and docking

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月27日

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  • Salma Kadda,
  • Oussama Khibech,
  • El Hassania Loukili,
  • Raffaele Conte,
  • Khalil Azzaoui,
  • Sabir Ouahhoud,
  • Belkheir Hammouti,
  • Hana Caid Serghini,
  • Taibi Ben Hadda,
  • Shehdeh Jodeh,
  • Abdelmajid Belabed

摘要

This study reports the chemical profiling and antimicrobial potential of Opuntia ficus-indica seed oil from Eastern Morocco, with emphasis on pharmacologically relevant constituents and valorization of an underexploited by-product. Seed oil was obtained by cold mechanical pressing and characterized using GC–MS (fatty acids and volatile profile), HPLC–DAD (tocopherols), and UHPLC–MS/MS (phenolic constituents). The oil exhibited a PUFA-rich profile dominated by linoleic acid (73.94%), with palmitic and stearic acids as major saturated components, while oleic acid was not detected under our analytical conditions. Tocopherol analysis revealed a high γ-tocopherol level (657.52 mg/kg). UHPLC–MS/MS enabled annotation of multiple phenolic compounds, including arbutin and kaempferol as major constituents. In vitro antibacterial assays showed no inhibition against Staphylococcus aureus and Streptococcus spp. (inhibition zone < 7 mm), whereas moderate-to-high activity was observed against Escherichia coli (11.6 ± 0.64 mm) and Klebsiella spp. (15.6 ± 0.51 mm). In silico POM analysis supported favorable drug-likeness/toxicological profiles for arbutin and kaempferol. Overall, these results support O. ficus-indica seed oil as a chemically rich natural matrix with promising antioxidant and antibacterial potential.