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<p>This case-control study investigated the association between Body Mass Index (BMI), cardiovascular risk factors, and Meniere’s disease (MD). We enrolled 100 patients with definite MD and 100 age- and sex-matched controls. We assessed BMI categories, cardiovascular risk factors, and medication use. Hearing loss was evaluated via pure-tone audiometry. Multivariable logistic regression, adjusted for confounders, identified independent associations. BMI distribution differed significantly. Overweight was more prevalent in MD patients (73% vs. 22%), while normal weight was less common (19% vs. 72%; <i>p</i> &lt; 0.001). After adjustment, overweight remained independently associated with MD (aOR = 3.85, 95% CI: 1.92–7.72, <i>p</i> &lt; 0.001). Warfarin showed a protective association (aOR = 0.32, 95% CI: 0.11–0.94, <i>p</i> = 0.04). Associations for diabetes and dyslipidemia lost significance after adjustment. Overweight is a strong, independent risk factor for MD. The protective association of warfarin suggests potential microvascular mechanisms, highlighting the importance of weight management in MD patients.</p>

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Association of body mass index and cardiovascular risk profile with ménière’s disease: A case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月20日

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  • Shadman Nemati,
  • Alia Saberi,
  • Yousef Reyhani,
  • Mehrgan khanhakimi,
  • Negar Hosseinpour,
  • Sevil Nasirmohtaram

摘要

This case-control study investigated the association between Body Mass Index (BMI), cardiovascular risk factors, and Meniere’s disease (MD). We enrolled 100 patients with definite MD and 100 age- and sex-matched controls. We assessed BMI categories, cardiovascular risk factors, and medication use. Hearing loss was evaluated via pure-tone audiometry. Multivariable logistic regression, adjusted for confounders, identified independent associations. BMI distribution differed significantly. Overweight was more prevalent in MD patients (73% vs. 22%), while normal weight was less common (19% vs. 72%; p < 0.001). After adjustment, overweight remained independently associated with MD (aOR = 3.85, 95% CI: 1.92–7.72, p < 0.001). Warfarin showed a protective association (aOR = 0.32, 95% CI: 0.11–0.94, p = 0.04). Associations for diabetes and dyslipidemia lost significance after adjustment. Overweight is a strong, independent risk factor for MD. The protective association of warfarin suggests potential microvascular mechanisms, highlighting the importance of weight management in MD patients.