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<p><i>Metapanax delavayi</i> (Franch.) J. Wen &amp; Frodin (Araliaceae) is a plant with both medicinal and edible value, but there is no study examining its effects on skin neurogenic inflammation. We investigated the anti-neurogenic inflammatory and soothing potential of <i>Metapanax delavayi</i> extract (MDE) in <i>vitro</i> using SH-SY5Y cells activated by capsaicin and HaCaT cells stimulated by substance P, and in <i>vivo</i> using a heat-induced zebrafish model. We found that MDE significantly inhibited TRPV1 activation and intracellular calcium influx, down-regulated neuropeptides (CGRP, NGF, substance P) and proinflammatory cytokines (IL-1α, IL-6, IL-8), and regulated emotion-related hormones (decreased cortisol, increased β-endorphin). It also reduced heat-induced hypermotility in zebrafish. Critically, the mechanistic study suggests that biological activity may be associated with the inactivation of the CRHR1/POMC/MC1R signaling pathway. Collectively, these findings indicate that MDE possesses significant potential as a natural skincare ingredient for counteracting neurogenic inflammation associated with sensitive skin.</p>

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Metapanax delavayi extract as a neurocutaneous modulator via CRHR1/POMC/MC1R signaling

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月9日

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  • Anming Zhu,
  • Junxi Liu,
  • Youyun Liu,
  • Rui Xu,
  • Yonglei Yuan,
  • Qiwen Sun,
  • Feifei Wang,
  • Liping Qu

摘要

Metapanax delavayi (Franch.) J. Wen & Frodin (Araliaceae) is a plant with both medicinal and edible value, but there is no study examining its effects on skin neurogenic inflammation. We investigated the anti-neurogenic inflammatory and soothing potential of Metapanax delavayi extract (MDE) in vitro using SH-SY5Y cells activated by capsaicin and HaCaT cells stimulated by substance P, and in vivo using a heat-induced zebrafish model. We found that MDE significantly inhibited TRPV1 activation and intracellular calcium influx, down-regulated neuropeptides (CGRP, NGF, substance P) and proinflammatory cytokines (IL-1α, IL-6, IL-8), and regulated emotion-related hormones (decreased cortisol, increased β-endorphin). It also reduced heat-induced hypermotility in zebrafish. Critically, the mechanistic study suggests that biological activity may be associated with the inactivation of the CRHR1/POMC/MC1R signaling pathway. Collectively, these findings indicate that MDE possesses significant potential as a natural skincare ingredient for counteracting neurogenic inflammation associated with sensitive skin.