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<p>Quantitative PET studies require a measurement of the arterial input function (AIF), the time-dependent radiotracer concentration in arterial blood plasma. Several groups are developing non-invasive detectors to measure the AIF from the radial artery. This study quantifies the depth and cross-sectional area of the radial artery and accompanying veins at different wrist positions using ultrasound. These anatomical data will guide the design of a non-invasive, wrist-worn detector for AIF acquisition—a practical, patient-friendly alternative to invasive blood sampling. Ultrasound imaging of the wrist was performed on 154 healthy individuals at specified distances from the distal wrist crease (2 <i>cm</i>, 4 <i>cm</i>, and 6 <i>cm</i>). The depths of the radial artery at distances of 2 <i>cm</i>, 4 <i>cm</i>, and 6 <i>cm</i> from the distal wrist crease are 3.36 (1.25) <i>mm</i>, 4.08 (1.81) <i>mm</i>, and 4.66 (2.23) <i>mm</i>, respectively (mean (SD)). Similarly, the cross-sectional areas of the radial artery at these distances are 4.23 (1.75) <i>mm</i><InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(^{2}\)</EquationSource> </InlineEquation>, 3.92 (1.71) <i>mm</i><InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(^{2}\)</EquationSource> </InlineEquation>, and 3.90 (1.88) <i>mm</i><InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(^{2}\)</EquationSource> </InlineEquation>, respectively. The radial artery becomes larger and more superficial near the wrist, suggesting a radiation detector be placed 2 <i>cm</i> from the distal wrist crease on the left arm, where it is generally more superficial than on the right.</p>

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Ultrasound wrist mapping to develop a noninvasive radiation detector for dynamic positron emission tomography

  • 期刊论文

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  • 发表日期：

    2026年2月8日

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  • Marc-Antoine Leclerc,
  • Mihai Mesko,
  • Youstina Daoud,
  • Shirin A. Enger

摘要

Quantitative PET studies require a measurement of the arterial input function (AIF), the time-dependent radiotracer concentration in arterial blood plasma. Several groups are developing non-invasive detectors to measure the AIF from the radial artery. This study quantifies the depth and cross-sectional area of the radial artery and accompanying veins at different wrist positions using ultrasound. These anatomical data will guide the design of a non-invasive, wrist-worn detector for AIF acquisition—a practical, patient-friendly alternative to invasive blood sampling. Ultrasound imaging of the wrist was performed on 154 healthy individuals at specified distances from the distal wrist crease (2 cm, 4 cm, and 6 cm). The depths of the radial artery at distances of 2 cm, 4 cm, and 6 cm from the distal wrist crease are 3.36 (1.25) mm, 4.08 (1.81) mm, and 4.66 (2.23) mm, respectively (mean (SD)). Similarly, the cross-sectional areas of the radial artery at these distances are 4.23 (1.75) mm \(^{2}\) , 3.92 (1.71) mm \(^{2}\) , and 3.90 (1.88) mm \(^{2}\) , respectively. The radial artery becomes larger and more superficial near the wrist, suggesting a radiation detector be placed 2 cm from the distal wrist crease on the left arm, where it is generally more superficial than on the right.