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<p><i>MALAT1</i> is a long non-coding RNA (lncRNA) with altered expression in many cancers but poorly studied in B-cell neoplasms like mantle cell lymphoma (MCL), a very aggressive B-cell lymphoma. To elucidate the role of <i>MALAT1</i> in MCL we have investigated its expression in 219 primary tumors using microarray data. We also analyzed the expression of its natural antisense transcript (<i>TALAM1</i>), which is key for the processing of <i>MALAT1</i> RNA to its active isoform. High expression of <i>MALAT1/TALAM1</i> lncRNAs was consistently linked to favorable clinical behavior in MCL, independently of other alterations previously described to influence MCL prognosis. In concordance with the observed clinical association, we found that the increased expression of these lncRNAs was inversely associated with gene signatures related to a proliferative and activation phenotype (MCL35-proliferation/BCR signaling signatures) in MCL samples from lymph nodes as peripheral blood. Finally, functional studies of <i>MALAT1</i> in MCL primary samples showed that its levels were downregulated by microenvironmental stimuli and EZH2 activity, a known epigenetic factor induced by pro-proliferative stimuli and previously related with poor MCL prognosis. Altogether, these data support the favorable prognostic value of <i>MALAT1</i> expression in MCL, and the <i>MALAT1</i> dual role as oncogene or tumor suppressor in different neoplasms.</p>

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The expression of MALAT1 long non-coding RNA is associated with good prognosis in mantle cell lymphoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月7日

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  • Elena María Fernández-Garnacho,
  • Cristina Martínez-Muñoz,
  • Ferran Nadeu,
  • Guillem Clot,
  • Juan García Valero,
  • Ferran Araujo-Ayala,
  • Ares Martínez-Farran,
  • Anna De Bolòs,
  • Dolors Colomer,
  • Pablo Mozas,
  • Andrea Rivero,
  • Eva Giné,
  • Armando López-Guillermo,
  • Itziar Salaverria,
  • Cristina López,
  • Sílvia Beà,
  • Virginia Amador,
  • Santiago Demajo,
  • Pedro Jares,
  • José Ignacio Martín-Subero,
  • Patricia Pérez-Galán,
  • Elías Campo,
  • Lluís Hernández

摘要

MALAT1 is a long non-coding RNA (lncRNA) with altered expression in many cancers but poorly studied in B-cell neoplasms like mantle cell lymphoma (MCL), a very aggressive B-cell lymphoma. To elucidate the role of MALAT1 in MCL we have investigated its expression in 219 primary tumors using microarray data. We also analyzed the expression of its natural antisense transcript (TALAM1), which is key for the processing of MALAT1 RNA to its active isoform. High expression of MALAT1/TALAM1 lncRNAs was consistently linked to favorable clinical behavior in MCL, independently of other alterations previously described to influence MCL prognosis. In concordance with the observed clinical association, we found that the increased expression of these lncRNAs was inversely associated with gene signatures related to a proliferative and activation phenotype (MCL35-proliferation/BCR signaling signatures) in MCL samples from lymph nodes as peripheral blood. Finally, functional studies of MALAT1 in MCL primary samples showed that its levels were downregulated by microenvironmental stimuli and EZH2 activity, a known epigenetic factor induced by pro-proliferative stimuli and previously related with poor MCL prognosis. Altogether, these data support the favorable prognostic value of MALAT1 expression in MCL, and the MALAT1 dual role as oncogene or tumor suppressor in different neoplasms.