<p>Hydraulic fracturing is a key technology for enhancing coalbed methane recovery. Preconditioning the reservoir with acidizing or oxidative fluids can significantly improve stimulation outcomes; however, comparative studies evaluating these fluids in coal seams are still limited. In this work, deep coal samples (depth &gt; 2500&#xa0;m) were treated with five different pre-fracturing fluids—slick water (PAM), hydrochloric acid (HCl), hydrochloric and hydrofluoric (HCl + HF) acid, sodium hypochlorite (NaClO), and hydrogen peroxide (H₂O₂)—and their effects on porosity, permeability, and mechanical properties were systematically compared using low-field NMR, SEM, and mechanical testing. The potential relationships between changes in mechanical parameters and pore-fracture structure were also examined. Results show that all five fluids increased total porosity by 33.98 ~ 45.04%. The HCl + HF produced the most dramatic permeability enhancement (13,561.54%), whereas HCl alone reduced permeability by 78.01%. Moreover, HCl + HF led to the most pronounced reduction in both compressive and tensile strength. Kendall correlation analysis revealed several significant relationships: Young’s modulus (<i>E</i>) correlated negatively with total porosity (<i>φ</i>_<i>t</i>) and average roughness (<i>R</i>_<i>a</i>); Poisson’s ratio (<i>ν</i>) showed a positive correlation with <i>φ</i>_<i>t</i>; and tensile strength (<i>R</i>_<i>t</i>) was negatively correlated with <i>R</i>_<i>a</i>. These findings provide practical insights for selecting pre-fracturing fluids based on desired reservoir weakening or permeability enhancement objectives.</p>