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<p>This study aims to characterize the histomorphology of mixed odontogenic tumors, using mathematical morphology algorithms applied to digital images. Five cases of primordial odontogenic tumor (POT), 5 cases of ameloblastic fibroma, 5 cases of developing odontoma (DO), and 5 cases of tooth germs (TG) were analyzed. Histological sections stained with Haematoxylin &amp; Eosin were digitized and the epithelial compartments were segmented into ‘virtual cells’ to further characterize the tissue compartment architecture. A comparison of the mean area of virtual epithelial cells in the entities investigated showed that, despite data distribution between the entities being similar, statistically significant differences (p &lt; 0.001) were found, being larger for DO and smaller for AF. Additionally, DO exhibits a broader data distribution of the area compared to the other entities. Significant differences were not found between TG and POT without subepithelial condensation. Quantitative tissue analysis showed that, in focal areas, POT more closely resembles TG than other mixed odontogenic tumors. These findings suggest that virtual cell–based morphometric analysis may provide complementary quantitative information in diagnostically challenging cases, although validation in larger datasets is required.</p>

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Algorithmic analysis of the structure of mixed odontogenic tumors

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月6日

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  • Vanesa Pereira-Prado,
  • Estefanía Sicco,
  • Felipe Martins Silveira,
  • Lauren Frenzel Schuch,
  • Keith Hunter,
  • Sven Eric Niklander,
  • Wanninayake Mudiyanselage Tilakaratne,
  • Ricardo Santiago Gomez,
  • Gabriel Landini,
  • Ronell Bologna-Molina

摘要

This study aims to characterize the histomorphology of mixed odontogenic tumors, using mathematical morphology algorithms applied to digital images. Five cases of primordial odontogenic tumor (POT), 5 cases of ameloblastic fibroma, 5 cases of developing odontoma (DO), and 5 cases of tooth germs (TG) were analyzed. Histological sections stained with Haematoxylin & Eosin were digitized and the epithelial compartments were segmented into ‘virtual cells’ to further characterize the tissue compartment architecture. A comparison of the mean area of virtual epithelial cells in the entities investigated showed that, despite data distribution between the entities being similar, statistically significant differences (p < 0.001) were found, being larger for DO and smaller for AF. Additionally, DO exhibits a broader data distribution of the area compared to the other entities. Significant differences were not found between TG and POT without subepithelial condensation. Quantitative tissue analysis showed that, in focal areas, POT more closely resembles TG than other mixed odontogenic tumors. These findings suggest that virtual cell–based morphometric analysis may provide complementary quantitative information in diagnostically challenging cases, although validation in larger datasets is required.