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<p>This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The <i>in-vitro</i> anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL &gt; NiL &gt; ZnL &gt; VOL &gt; HL.</p>

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Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月7日

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  • Laila H. Abdel-Rahman,
  • Doaa Abou El-ezz,
  • Abdel-Mawgoud M. Abdel-Mawgoud,
  • Mohamed R. Shehata,
  • Mahmoud Abd El Aleem Ali Ali El-Remaily,
  • Mohamed Abdel-Hameed,
  • Shaaban K. Mohamed

摘要

This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL.