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<p>This study aimed to analyze the phytochemical constituents and evaluate the antimicrobial effects of ethanolic extracts from <i>Matricaria chamomilla</i> (chamomile) leaves and flowers against clinical bacterial isolates collected from Ibb City, Yemen. Phytochemical screening revealed presence of alkaloids, tannins, sterols, and terpenoids in both leaves and flowers, while flavonoids, glycosides, saponins, and amino acids were absent. Antibacterial activity was assessed using inhibition zone diameters against pathogens including <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Salmonella</i> spp., and <i>Pseudomonas aeruginosa</i>. The extracts showed significant antimicrobial activity, especially against <i>S. aureus</i>, with leaf extract showing a 24&#xa0;mm inhibition zone and flower extract 15&#xa0;mm. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests confirmed the potent bactericidal effects at low extract concentrations (100&#xa0;mg/mL). These findings underscore the therapeutic potential of <i>M. chamomilla</i> as a natural antimicrobial agent relevant to combating bacterial infections, especially in the local Yemeni context. Further studies are recommended to isolate active compounds and evaluate mechanisms of action.</p>

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Phytochemical composition and antimicrobial activity of Matricaria chamomilla ethanolic extracts against clinical bacterial isolates in Ibb City, Yemen

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月3日

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  • Abeer Esmail,
  • Asmaa Hassan,
  • Khadeja Almuntaser,
  • Nasibh Alashari,
  • Nosiubah Alkadry,
  • Reem Alnahi,
  • Halah Alhagwa,
  • Rehab Hamza,
  • Nadia Alhubaishy,
  • Ammar AL-Farga,
  • Tasneem Alnuzaili

摘要

This study aimed to analyze the phytochemical constituents and evaluate the antimicrobial effects of ethanolic extracts from Matricaria chamomilla (chamomile) leaves and flowers against clinical bacterial isolates collected from Ibb City, Yemen. Phytochemical screening revealed presence of alkaloids, tannins, sterols, and terpenoids in both leaves and flowers, while flavonoids, glycosides, saponins, and amino acids were absent. Antibacterial activity was assessed using inhibition zone diameters against pathogens including Staphylococcus aureus, Escherichia coli, Salmonella spp., and Pseudomonas aeruginosa. The extracts showed significant antimicrobial activity, especially against S. aureus, with leaf extract showing a 24 mm inhibition zone and flower extract 15 mm. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests confirmed the potent bactericidal effects at low extract concentrations (100 mg/mL). These findings underscore the therapeutic potential of M. chamomilla as a natural antimicrobial agent relevant to combating bacterial infections, especially in the local Yemeni context. Further studies are recommended to isolate active compounds and evaluate mechanisms of action.