Scholarlink

<p><i>Erysipelothrix rhusiopathiae</i> is a pathogenic bacterium infecting both humans and animals and causing erysipeloid, a disease that can leads to osteoarticular conditions, abscesses, and septic arthritis. Here, we report the sequenced ancient genome of <i>E. rhusiopathiae</i> obtained from teeth of an Alan child who lived in the North Caucasus in 6th–7th centuries AD. Differential diagnosis using paleopathological methods suggested that the child suffered from tuberculosis. However, analysis of tooth pulp revealed no signs of <i>M. tuberculosis</i> but a massive presence of ancient <i>E. rhusiopathiae</i> DNA. A complete high-quality ancient <i>E. rhusiopathiae</i> genome was assembled and found to belong to clade II of the extant <i>E. rhusiopathiae</i> phylogeny tree<i>,</i> nested in a subclade of closely related modern isolates infecting wild boars and domestic pigs. The ancient genome belongs to serotype 5 and encodes the key <i>E. rhusiopathiae</i> virulence factor SpaA group 1 along with vancomycin resistance genes. We propose that infection with <i>E. rhusiopathiae</i>, alone or together with other pathogens, is the likely cause of skeletal pathologies observed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

An ancient Erysipelothrix rhusiopathiae genome recovered from 1400-year-old human remains in the Northern Caucasus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月3日

查看全文
  • Andrey A. Kritsky,
  • Natalia Y. Berezina,
  • Alexandra O. Ivanova,
  • Dmitry A. Sutormin,
  • Egor I. Botsmanov,
  • Alla A. Perevozchikova,
  • Anna A. Kadieva,
  • Tatiana R. Tsedilina,
  • Matvey V. Kolesnik,
  • Anastasia V. Pavlova,
  • Sergej V. Demidenko,
  • Evgeny I. Klimuk,
  • Alexandra P. Buzhilova,
  • Konstantin V. Severinov

摘要

Erysipelothrix rhusiopathiae is a pathogenic bacterium infecting both humans and animals and causing erysipeloid, a disease that can leads to osteoarticular conditions, abscesses, and septic arthritis. Here, we report the sequenced ancient genome of E. rhusiopathiae obtained from teeth of an Alan child who lived in the North Caucasus in 6th–7th centuries AD. Differential diagnosis using paleopathological methods suggested that the child suffered from tuberculosis. However, analysis of tooth pulp revealed no signs of M. tuberculosis but a massive presence of ancient E. rhusiopathiae DNA. A complete high-quality ancient E. rhusiopathiae genome was assembled and found to belong to clade II of the extant E. rhusiopathiae phylogeny tree, nested in a subclade of closely related modern isolates infecting wild boars and domestic pigs. The ancient genome belongs to serotype 5 and encodes the key E. rhusiopathiae virulence factor SpaA group 1 along with vancomycin resistance genes. We propose that infection with E. rhusiopathiae, alone or together with other pathogens, is the likely cause of skeletal pathologies observed.