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<p>Silver nanoparticles (AgNPs) are well-known for their distinctive optical, electronic, and antimicrobial properties, enabling versatile applications in biosensors, photonics, electronics, drug delivery, and antimicrobial treatments. The biological synthesis approach offers a sustainable and eco-friendly alternative to traditional physical and chemical methods. Metal and metal oxide nanoparticles synthesized from plant extracts are emerging as promising agents with notable medicinal potential. This study presents a cost-effective, simple, and eco-friendly approach for synthesizing silver nanoparticles (AgNPs) through the reduction of Ag<sup>+</sup> ions to metallic silver (Ag<sup>0</sup>) using an aqueous extract of <i>Alcea rosea</i> leaves. The synthesized nanoparticles were characterized using various techniques, including UV–visible, FTIR, XRD, FESEM, and EDX. Biological activities were evaluated for their antioxidant, antibacterial, and anticancer assays. The AgNPs demonstrated moderate antibacterial activity against <i>Staphylococcus aureus</i> and <i>Shigella sonnei</i>, as evidenced by moderate minimum inhibitory and bactericidal concentrations, and mild DPPH free radical scavenging activity with an IC<sub>50</sub> value of 80.05 ± 1.53&#xa0;µg/mL. The nanoparticles exhibited significant anticancer activity against cervical cancer cell lines, with an IC<sub>50</sub> of 54.46 ± 1.67 µg/mL. These findings suggest that the synthesized AgNPs have promising potential for medical applications, especially in drug development.</p>

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Plant-mediated synthesis of silver nanoparticles using Alcea rosea leaf aqueous extract and evaluation of the biological activities

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月30日

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  • Indra Ojha,
  • Prem Singh Saud,
  • Dipak Raj Jaishi,
  • Yagya Raj Rosyara,
  • Anil Ojha,
  • Nepal Rama Devi,
  • Prem Raj Joshi,
  • Hem Raj Pant

摘要

Silver nanoparticles (AgNPs) are well-known for their distinctive optical, electronic, and antimicrobial properties, enabling versatile applications in biosensors, photonics, electronics, drug delivery, and antimicrobial treatments. The biological synthesis approach offers a sustainable and eco-friendly alternative to traditional physical and chemical methods. Metal and metal oxide nanoparticles synthesized from plant extracts are emerging as promising agents with notable medicinal potential. This study presents a cost-effective, simple, and eco-friendly approach for synthesizing silver nanoparticles (AgNPs) through the reduction of Ag+ ions to metallic silver (Ag0) using an aqueous extract of Alcea rosea leaves. The synthesized nanoparticles were characterized using various techniques, including UV–visible, FTIR, XRD, FESEM, and EDX. Biological activities were evaluated for their antioxidant, antibacterial, and anticancer assays. The AgNPs demonstrated moderate antibacterial activity against Staphylococcus aureus and Shigella sonnei, as evidenced by moderate minimum inhibitory and bactericidal concentrations, and mild DPPH free radical scavenging activity with an IC50 value of 80.05 ± 1.53 µg/mL. The nanoparticles exhibited significant anticancer activity against cervical cancer cell lines, with an IC50 of 54.46 ± 1.67 µg/mL. These findings suggest that the synthesized AgNPs have promising potential for medical applications, especially in drug development.