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<p>The Oxford (split) and Japanese Histological Grade (JHG [lumped]) classifications of immunoglobulin A nephropathy (IgAN) are widely used in Japan. We compared their prognostic ability and explored the benefits of combining them. Data were from a prospective IgAN cohort (2005–2015). The primary endpoint was a ≥ 50% decline in estimated glomerular filtration rate (eGFR) or end-stage renal disease. Cox regression with Uno C assessed prognostic discrimination. The integrated discrimination improvement index evaluated the added value of histologic to clinical variables (eGFR, urinary protein, and mean arterial pressure) at 1, 5, and 10&#xa0;years. Kaplan–Meier analysis stratified patients into JHG 1 and 2–4 to assess the prognostic value of mesangial hypercellularity (M) and interstitial fibrosis/tubular atrophy (T). Among 938 patients (median follow-up: 66&#xa0;months), 58 (6.2%) reached the endpoint. M and T (Oxford) and JHG were significantly associated with outcomes. Both systems showed good discrimination (Uno C: 0.83 and 0.86). Adding Oxford to clinical variables improved prediction at 5 and 10&#xa0;years; adding JHG improved prediction at 1, 5, and 10&#xa0;years. M and T were predictive in JHG 2–4 but not in JHG 1. Both classifications demonstrated comparable discrimination. Their combined use can help enhance predictive precision.</p>

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Comparison of Oxford versus Japanese Histological Grading to predict renal function decline in IgA nephropathy: a Japanese prospective cohort study

  • 期刊论文

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  • 发表日期：

    2026年2月2日

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  • Ryoko Sakaguchi,
  • Kensuke Joh,
  • Shiko Honma,
  • Akira Shimizu,
  • Akinori Hashiguchi,
  • Ritsuko Katafuchi,
  • Masako Nishikawa,
  • Kentaro Koike,
  • Keita Hirano,
  • Nobuo Tsuboi,
  • Tetsuya Kawamura,
  • Takashi Yokoo,
  • Yusuke Suzuki

摘要

The Oxford (split) and Japanese Histological Grade (JHG [lumped]) classifications of immunoglobulin A nephropathy (IgAN) are widely used in Japan. We compared their prognostic ability and explored the benefits of combining them. Data were from a prospective IgAN cohort (2005–2015). The primary endpoint was a ≥ 50% decline in estimated glomerular filtration rate (eGFR) or end-stage renal disease. Cox regression with Uno C assessed prognostic discrimination. The integrated discrimination improvement index evaluated the added value of histologic to clinical variables (eGFR, urinary protein, and mean arterial pressure) at 1, 5, and 10 years. Kaplan–Meier analysis stratified patients into JHG 1 and 2–4 to assess the prognostic value of mesangial hypercellularity (M) and interstitial fibrosis/tubular atrophy (T). Among 938 patients (median follow-up: 66 months), 58 (6.2%) reached the endpoint. M and T (Oxford) and JHG were significantly associated with outcomes. Both systems showed good discrimination (Uno C: 0.83 and 0.86). Adding Oxford to clinical variables improved prediction at 5 and 10 years; adding JHG improved prediction at 1, 5, and 10 years. M and T were predictive in JHG 2–4 but not in JHG 1. Both classifications demonstrated comparable discrimination. Their combined use can help enhance predictive precision.