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<p>Strontium-doped wollastonite glass-ceramics with varying Sr concentrations (0.125, 0.25, and 0.50 wt%) were successfully synthesized via a melt-quenching technique and comprehensively evaluated for structural, physical, and biological performance, including in vitro biocompatibility, antimicrobial activity, and cytotoxicity. Characterization using DTA, XRD, and FE-SEM/EDX confirmed progressive hydroxyapatite (HA) formation following 28 days of immersion in simulated body fluid (SBF), with XRD revealing a reduction in wollastonite peaks and distinct HA signals, particularly in Sr-containing samples. FTIR spectra showed intensified phosphate absorption bands, while FE-SEM/EDX analyses highlighted a morphological shift from plate-like structures to needle-like HA crystals. Strontium doping was found to play a key role in guiding HA crystallization pathways while supporting wollastonite’s intrinsic isovalent cation exchange capacity. Among all compositions, the W3Sr sample (0.5 wt% Sr) exhibited the best balance of mechanical properties and biological efficacy. Biologically, the material demonstrated dose-dependent antifungal activity against <i>Aspergillus niger</i> (11–18&#xa0;mm IZD) and <i>Fusarium solani</i> (10–16&#xa0;mm IZD), no antibacterial activity, and excellent cytocompatibility with BJ1 human fibroblasts. Overall, this Sr-doped wollastonite system shows strong potential for next-generation orthopedic and dental applications, combining Sr-mediated bioactivity, mechanical strength, antifungal efficacy, and cell compatibility.</p>

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Characterization, in-vitro biological and antimicrobial testing of replacing Sr/Ca in wollastonite (Ca1 − x Srx SiO3) glass-ceramics

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月11日

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  • H. K. Abd El-Hamid,
  • Gehan T. El-Bassyouni,
  • Amira M. M. Amin,
  • Abeer A. Abd El-Aty,
  • Emad M. M. Ewais,
  • Esmat M. A. Hamzawy

摘要

Strontium-doped wollastonite glass-ceramics with varying Sr concentrations (0.125, 0.25, and 0.50 wt%) were successfully synthesized via a melt-quenching technique and comprehensively evaluated for structural, physical, and biological performance, including in vitro biocompatibility, antimicrobial activity, and cytotoxicity. Characterization using DTA, XRD, and FE-SEM/EDX confirmed progressive hydroxyapatite (HA) formation following 28 days of immersion in simulated body fluid (SBF), with XRD revealing a reduction in wollastonite peaks and distinct HA signals, particularly in Sr-containing samples. FTIR spectra showed intensified phosphate absorption bands, while FE-SEM/EDX analyses highlighted a morphological shift from plate-like structures to needle-like HA crystals. Strontium doping was found to play a key role in guiding HA crystallization pathways while supporting wollastonite’s intrinsic isovalent cation exchange capacity. Among all compositions, the W3Sr sample (0.5 wt% Sr) exhibited the best balance of mechanical properties and biological efficacy. Biologically, the material demonstrated dose-dependent antifungal activity against Aspergillus niger (11–18 mm IZD) and Fusarium solani (10–16 mm IZD), no antibacterial activity, and excellent cytocompatibility with BJ1 human fibroblasts. Overall, this Sr-doped wollastonite system shows strong potential for next-generation orthopedic and dental applications, combining Sr-mediated bioactivity, mechanical strength, antifungal efficacy, and cell compatibility.